Case report| Volume 18, ISSUE 2, P167-170, March 1989

Autoimmune neutropenia and thrombocytopenia associated with development of antibodies to human immunodeficiency virus

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      We report on two patients with acute human immunodeficiency virus (HIV) infection, who developed an infectious mononucleosis-like clinical episode with thrombocytopenia and granulocytopenia. In both cases we detected the presence of IgG antigranulocyte antibodies and in one case the presence of IgG, IgM and IgA antiplatelet antibodies. The mechanisms of these cytopenias are discussed. The association between such autoimmune cytopenias and acute HIV infection has not been previously reported.
      We suggest testing for HIV seroconversion in patients with a seronegative infectious mononucleosis-like syndrome belonging to groups with a high risk for HIV infection.
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        • Spivak JL
        • Bender BS
        • Quinn TC
        Hematological abnormalities in the acquired immune deficiency syndrome.
        Am J Med. 1984; 77: 224-228
        • Morris L
        • Distenfeld A
        • Amorosi E
        • Karpatkin S
        Autoimmune thrombocytopenia in homosexual men.
        Ann Intern Med. 1982; 96: 714-717
        • Murphy MF
        • Metcalfe P
        • Waters AH
        • et al.
        Immune neutropenia in homosexual men.
        Lancet. 1985; : 217-218
        • Stricker RB
        • Abrams DI
        • Corash L
        • Shuman MA
        Target platelet antigen in homosexual men with immune thrombocytopenia.
        New Engl J Med. 1985; 313: 1375-1380
        • Cooper DA
        • Gold J
        • MacLean P
        • et al.
        Acute AIDS retrovirus infection.
        Lancet. 1985; i: 504-537
        • Ho DD
        • Sarngadharan MG
        • Resnick L
        • Dimarzo-Veronese F
        • Rota TR
        • Hirsch MS
        Primary human T-lymphotropic virus type III infection.
        Ann Intern Med. 1985; 103: 880-883
        • Lima J
        • Ribera A
        • Garcia-Bragado F
        • Monteagudo M
        • Martin-Vega C
        • Bastida MT
        Antiplatelet antibodies in primary infection by human immunodeficiency virus.
        Ann Intern Med. 1987; 106: 333
        • Walsh CM
        • Nardi MA
        • Karpatkin S
        On the mechanism of thrombocytopenia purpura in sexually active homosexual men.
        New Engl J Med. 1984; 311: 635-659
        • Murphy MF
        • Metcalfe P
        • Waters AH
        • et al.
        Incidence and mechanism of neutropenia and thrombocytopenia in patients with human immunodeficiency virus infection.
        Br J Haematol. 1987; 66: 337-340
        • Minchinton RM
        • Frazer I
        Idiopathic neutropenia in homosexual men.
        Lancet. 1985; i: 936
        • Lelie J van der
        • Lange JMA
        • Goudsmit J
        • et al.
        Idiopathic neutropenia in homosexual men.
        Lancet. 1985; i: 936-937
        • Gardner FH
        • Bessman J
        Thrombocytopenia due to defective platelet production.
        in: Wolvey W Platelet disorders. W. B. Saunders, Antwerp1983: 23-38