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Original article| Volume 18, ISSUE 2, P161-165, March 1989

Experience with itraconazole in cryptococcosis and aspergillosis

DOI:https://doi.org/10.1016/S0163-4453(89)91178-X
Experience with itraconazole in cryptococcosis and aspergillosis
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      Summary

      Cryptococcosis and aspergillosis in immunocompromised patients are extremely difficult clinical conditions to manage and treatment with available antifungal drugs often fails. Itraconazole, R-51211, Janssen Pharmaceutica, a new orally absorbed triazole, is a possible alternative drug which is potentially effective and nontoxic. Preliminary experience with 28 patients, eight with cryptococcosis and 20 with aspergillosis, is reported. Of these patients, 16 were immunocompromised (seven with the acquired immune-deficiency syndrome (AIDS), five heart transplant recipients and four with leukaemia or lymphoma). Overall, results of treatment were good (18 in remission, four markedly improved, four moderately improved and two failed). Prevention of relapses of cryptococcosis was obtained in all patients with AIDS on long-term itraconazole monotherapy (3 mg/kg). Treatment of invasive aspergillosis required a higher dosage (about 5 mg/kg) and prolonged administration. Besides its efficacy this antifungal agent allowed outpatient management.
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      Article info

      Publication history

      Accepted: June 17, 1988

      Identification

      DOI: https://doi.org/10.1016/S0163-4453(89)91178-X

      Copyright

      © 1989 The British Society for the Study of Infection. Published by Elsevier Inc.

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