This paper is only available as a PDF. To read, Please Download here.
Summary
Serological evidence of active infection with Epstein-Barr virus (EBV) was found in
25 of 124 patients (20%) with the post-viral fatigue syndrome (PVFS). In another study
on the same group of patients around 50 % were found to have evidence of chronic enterovirus
infection. No overlap was found between those patients with enterovirus infection
and those with active EBV infection. We suggest that there are multiple causes of
PVFS and that, in the absence of coexisting immunosuppressive disease which may itself
reactivate the virus, EBV may be the aetiological agent in a predominantly female
subgroup of patients with PVFS. Furthermore, the disease process in this subgroup
may be immunopathological in nature.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of InfectionAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Chronic enterovirus infection in patients with postviral fatigue syndrome.Lancet. 1988; i: 146-150
- Prevalence, incidence and persistence of EB virus antibody in young adults.New Engl J Med. 1970; 282: 361-365
- Failure in immunological control of the virus infection: Fatal infectious mononucleosis.in: Epstein MA Achong BG The Epstein-Barr virus: Recent advances. W Heinemann, Washington DC1986: 127
- Epstein-Barr virus specific immune defects in patients with persistent symptoms following infectious mononucleosis.Q J Med. 1986; 58: 111-121
- Epstein-Barr virus replication in oropharyngeal epithelial cells.New Engl J Med. 1984; 310: 1225-1230
- Leukocyte-transforming agent; prolonged excretion by patients with mononucleosis and excretion by normal individuals.J Infect Dis. 1973; 127: 471-473
- Long term T cell mediated immunity to Epstein-Barr virus in man. I. Complete regression of virus-induced transformation in cultures of seropositive donor leucocytes.Int J Cancer. 1978; 22: 662-668
- Studies on long term T-cell mediated immunity to Epstein-Barr virus in immunosuppressed renal allograft recipients.Int J Cancer. 1981; 28: 705-709
- Epstein-Barr virus nuclear antigen positive lymphoma after cyclosporin A treatment in a patient with renal allograft.Lancet. 1980; i: 1355-1356
- Epstein-Barr virus.in: Zuckerman AJ Banatvala JE Pattison JE Principles and practice of clinical virology. Wiley, London1987: 111-133
- Antibody responses to Epstein-Barr virus determined nuclear antigen EBNA-1 and EBNA-2 in acute and chronic Epstein-Barr virus infection.in: Proc Natl Acad Sci USA. 84. 1987: 570-574
- Characteristic T cell dysfunction in patients with chronic active Epstein-Barr virus infection (chronic infectious mononucleosis).J Immunol. 1985; 134: 3082-3088
- Chronic fatigue syndrome: A working case definition.Ann Intern Med. 1988; 108: 387-389
- Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection.Ann Intern Med. 1985; 102: 7-16
- The post-viral fatigue syndrome — an analysis of the findings in 50 cases.J Infect. 1985; 10: 211-222
- Persistent fatigue and depression in a patient with antibody to human B-lymphotropic virus.Lancet. 1987; ii: 36
- Immunofluorescence in cells derived from Burkitt's lymphoma.J Bacteriol. 1966; 91: 1248-1256
- Differential reactivity of human serums with early antigens induced by Epstein-Barr virus.Science. 1970; 169: 188-190
- Cellular localisation of an Epstein-Barr virus (EBV) associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines.Int J Cancer. 1973; 11: 499-520
- Stable transfection of a human lymphoma line by sub-genomic fragments of Epstein-Barr virus DNA to measure humoral and cellular immunity to the corresponding proteins.Int J Cancer. 1987; 40: 389-395
- Clinical diagnosis by laboratory methods.14th ed. Saunders, Chichester1969
- Diagnostic methods in clinical virology.3rd ed. Blackwell, Philadelphia1979
- Evidence for disregulation in the control of Epstein-Barr virus latency in patients with AIDS-related complex.Clin Exp Immunol. 1986; 66: 17-24
- A cluster of patients with a chronic mononucleosis-like syndrome.in: Is Epstein-Barr virus the cause?JAMA. 257. 1987: 2297-2302
- Neurological effects of recombinant human interferon.Br Med J. 1983; 286: 262-264
- Increased (2′-5′)-oligo-A synthetase activity in patients with prolonged illness associated with serological evidence of persistent Epstein-Barr virus infection.Lancet. 1982; i: 744
Article info
Publication history
Accepted:
October 2,
1988
Identification
Copyright
© 1989 The British Society for the Study of Infection. Published by Elsevier Inc.
