Advertisement

Overview of clinical studies with hepatitis B vaccine made by recombinant DNA

      This paper is only available as a PDF. To read, Please Download here.

      Summary

      The Merck, Sharp and Dohme hepatitis B vaccine formulated from HBsAg produced by a recombinant strain of Saccharomyces cerevisiae has proven to be highly immunogenic and safe. A 10 μg dose of the vaccine produced an anti-HBs response of ⩾ 10 IU/l in 91 % or more of healthy adults who completed the three-dose regimen. Children responded well to all levels of vaccine antigen utilised but developed maximum anti-HBs titres with 5 μg doses. The age of the vaccine recipient affected responsiveness. Younger adults (20–29 years) responded more rapidly and with higher anti-HBs titres than did older adults (⩾ 50 years). Children responded faster and with higher anti-HBs levels than younger adults. Clinical reactions reported after vaccination were mild and transient.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Infection
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • McAleer WJ
        • Buynak EB
        • Maigetter RZ
        • Wampler DE
        • Miller WJ
        • Hilleman MR
        Human hepatitis B vaccine from recombinant yeast.
        Nature. 1984; 307: 178-180
        • Scolnick EM
        • McLean AA
        • West DJ
        • McAleer WJ
        • Miller WJ
        • Buynak EB
        Clinical evaluation in healthy adults of a hepatitis B vaccine made by recombinant DNA.
        JAMA. 1984; 251: 2812-2815
        • Dienstag JL
        • Watkins E
        • Hinkle CA
        Recombinant yeast hepatitis B vaccine: Immunogenicity and safety.
        Hepatology. 1984; 4: 1077
        • Jilg W
        • Schmidt M
        • Zoulek G
        • Lorbeer B
        • Wilske B
        • Deinhardt F
        Clinical evaluation of a recombinant hepatitis B vaccine.
        Lancet. 1984; ii: 1174-1175
        • Davidson M
        • Krugman S
        Immunogenicity of recombinant yeast hepatitis B vaccine.
        Lancet. 1985; i: 108-109
        • Dandolos E
        • Roumeliotou-Karayannis A
        • Richardson SC
        • Papaevangelou G
        Safety and immunogenicity of a recombinant hepatitis B vaccine.
        J Med Virol. 1985; 17: 57-62
        • Hilleman MR
        • Weibel RE
        • Scolnick EM
        Recombinant yeast human hepatitis B vaccine.
        J Hong Kong Med Assoc. 1985; 37: 75-85
        • Heijtink RA
        • Kruining J
        • Bakker M
        • Schalm SW
        Immune response after vaccination with recombinant hepatitis B vaccine as compared to that after plasma-derived vaccine.
        Antiviral Res. 1985; : 273-279
        • Hollinger FB
        • Troisi CL
        • Pepe PE
        Anti-HBs responses to vaccination with a human hepatitis B vaccine made by recombinant DNA technology to yeast.
        J Infect Dis. 1986; 153: 156-159
        • Hollinger FB
        • Adam E
        • Heiberg D
        • Melnick J
        Response to hepatitis B vaccine in a young adult population.
        in: Szmuness W Alter HJ Maynard JE Viral hepatitis. Franklin Institute Press, Orlando, Florida1982: 451-466