Letter to the Editor|Articles in Press

Discordance between semi-quantitative nucleic acid detection of bacteria and quantitative bacteriology in sputum from patients with pneumonia

Published:February 28, 2023DOI:
      We read with interest the publication by Sivakumaran et al.,
      • Sivakumaran S.
      • Alsallakh M.A.
      • Lyons R.A.
      • Quint J.K.
      • Davies G.A.
      Estimating the contribution of respiratory pathogens to acute exacerbations of COPD using routine data.
      in which diagnostic microbiology was under-utilized for patients hospitalized with acute exacerbation of COPD in a population-based study in Wales, UK. In that study, bacteria were sought from sputum by traditional culture-based methods, whilst viruses were detected by nucleic acid amplification tests (NAATs); the authors highlight the potential impact of increased diagnostic testing on antibiotic stewardship.
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