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Letter to the Editor|Articles in Press

Discordance between semi-quantitative nucleic acid detection of bacteria and quantitative bacteriology in sputum from patients with pneumonia

Published:February 28, 2023DOI:https://doi.org/10.1016/j.jinf.2023.02.036
Discordance between semi-quantitative nucleic acid detection of bacteria and quantitative bacteriology in sputum from patients with pneumonia
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      We read with interest the publication by Sivakumaran et al.,
      • Sivakumaran S.
      • Alsallakh M.A.
      • Lyons R.A.
      • Quint J.K.
      • Davies G.A.
      Estimating the contribution of respiratory pathogens to acute exacerbations of COPD using routine data.
      J Infect. 2023; 86: 233-238
      in which diagnostic microbiology was under-utilized for patients hospitalized with acute exacerbation of COPD in a population-based study in Wales, UK. In that study, bacteria were sought from sputum by traditional culture-based methods, whilst viruses were detected by nucleic acid amplification tests (NAATs); the authors highlight the potential impact of increased diagnostic testing on antibiotic stewardship.
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      Article info

      Publication history

      Published online: February 28, 2023
      Accepted: February 24, 2023

      Publication stage

      In Press Journal Pre-Proof

      Identification

      DOI: https://doi.org/10.1016/j.jinf.2023.02.036

      Copyright

      © 2023 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

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