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Application of metagenomic next-generation sequencing in bloodstream infection regarding immunosuppression

Published:February 10, 2023DOI:
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        • Peng J.-M.
        • Du B.
        • Qin H.-Y.
        • Wang Q.
        • Shi Y.
        Metagenomic next-generation sequencing for the diagnosis of suspected pneumonia in immunocompromised patients.
        J Infect. 2021; 82: 22-27
        • Ohmoto A.
        • Fuji S.
        Infection profiles of different chemotherapy regimens and the clinical feasibility of antimicrobial prophylaxis in patients with DLBCL.
        Blood Rev. 2021; 46100738
        • Xie J.
        • Wang H.
        • Kang Y.
        • Zhou L.
        • Liu Z.
        • Qin B.
        • et al.
        The epidemiology of sepsis in Chinese ICUs: a national cross-sectional survey.
        Crit Care Med. 2020; 48: e209-e218
        • Shankar-Hari M.
        • Harrison D.A.
        • Ferrando-Vivas P.
        • Rubenfeld G.D.
        • Rowan K.
        Risk factors at index hospitalization associated with longer-term mortality in adult sepsis survivors.
        JAMA Netw Open. 2019; 2e194900
        • Goldberg B.
        • Sichtig H.
        • Geyer C.
        • Ledeboer N.
        • Weinstock G.M.
        Making the leap from research laboratory to clinic: challenges and opportunities for next-generation sequencing in infectious disease diagnostics.
        mBio. 2015; 6
        • Miao Q.
        • Ma Y.
        • Wang Q.
        • Pan J.
        • Zhang Y.
        • Jin W.
        • et al.
        Microbiological diagnostic performance of metagenomic next-generation sequencing when applied to clinical practice.
        Clin Infect Dis. 2018; 67: S231-S240
        • Jerome H.
        • Taylor C.
        • Sreenu V.B.
        • Klymenko T.
        • Filipe A.D.S.
        • Jackson C.
        • et al.
        Metagenomic next-generation sequencing aids the diagnosis of viral infections in febrile returning travellers.
        J Infect. 2019; 79: 383-388
        • Nie J.
        • Yang L.
        • Huang L.
        • Gao L.
        • Young K.H.
        • Le Grange J.M.
        • et al.
        Infection complications in febrile chimeric antigen receptor (CAR)-T recipients during the peri-CAR-T cell treatment period examined using metagenomic next-generation sequencing (mNGS).
        Cancer Commun. 2022; 42: 476-480
        • Davila S.
        • Halstead E.S.
        • Hall M.W.
        • Doctor A.
        • Telford R.
        • Holubkov R.
        • et al.
        Viral DNAemia and immune suppression in pediatric sepsis.
        Pediatr Crit Care Med. 2018; 19: e14-e22
        • Handous I.
        • Achour B.
        • Marzouk M.
        • Rouis S.
        • Hazgui O.
        • Brini I.
        • et al.
        Co-infections of human herpesviruses (CMV, HHV-6, HHV-7 and EBV) in non-transplant acute leukemia patients undergoing chemotherapy.
        Virol J. 2020; 17: 37