We read with interest that a recent article published in the Journal of Infection, described that the H3N8 avian influenza viruses (AIVs) that caused human infection
had originated from chickens.
1
Avian influenza H3N8 viruses were widely circulating in multiple avian hosts, including
wild birds, chickens, and ducks.
2
Of particular note is that sporadic cross-species transmission events of the H3N8
viruses had been reported for multiple mammalian species including dogs, pigs, horses,
seals, donkeys, and humans.
2
,3
Although H3N8 viruses were low pathogenic in birds with mild symptoms, H3N8 viruses
could cause severe respiratory disease in mammals with mammalian adaptive mutation.
4
Strikingly, during 2022, human infections with H3N8 influenza viruses had been reported
in China,
5
highlighting that H3N8 influenza viruses had resulted in spillover events and posed
a new threat to public health. Therefore, we have performed the genomic analysis to
explore the epidemiology, evolutionary dynamics, and adaptive mutations of H3N8 viruses.To read this article in full you will need to make a payment
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References
- Human infection with H3N8 avian influenza virus: a novel H9N2-original reassortment virus.J Infect. 2022; (Sep 1)
- PB1 S524G mutation of wild bird-origin H3N8 influenza A virus enhances virulence and fitness for transmission in mammals.Emerg Microbes Infect. 2021; 10 (Dec): 1038-1051
- Host-range shift of H3N8 canine influenza virus: a phylodynamic analysis of its origin and adaptation from equine to canine host.Vet Res. 2019; 50 (Oct 30): 87
- Emergence of fatal avian influenza in New England harbor seals.MBio. 2012; 3 (e00166-12)
- Human infection of avian influenza A H3N8 virus and the viral origins: a descriptive study.Lancet Microbe. 2022; (Sep 14)
- Emergence of chicken infection with novel reassortant H3N8 avian influenza viruses genetically close to human H3N8 isolate, China.Emerg Microbes Infect. 2022; (Sep 23): 1-10
- Resurgence of H5N6 avian influenza virus in 2021 poses new threat to public health.Lancet Microbe. 2022; (Jun 21)
- Genetic diversity, phylogeography, and evolutionary dynamics of highly pathogenic avian influenza A (H5N6) viruses.Virus Evol. 2020; 6 (Julveaa079)
- Genomic evolution, transmission dynamics, and pathogenicity of avian influenza A (H5N8) viruses emerging in China, 2020.Virus Evol. 2021; 7 (Jan): veab046
- Divergent reassortment and transmission dynamics of highly pathogenic avian influenza A(H5N8) virus in birds of china during 2021.Front Microbiol. 2022; 13913551
Article info
Publication history
Published online: November 16, 2022
Accepted:
November 13,
2022
Identification
Copyright
© 2023 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
