Letter to the Editor| Volume 86, ISSUE 2, e36-e39, February 2023

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H3N8 subtype avian influenza virus originated from wild birds exhibited dual receptor-binding profiles

Published:October 19, 2022DOI:


      • Three H3N8 subtype low pathogenic avian influenza viruses were isolated from wild birds in China during the ordinary surveillance.
      • The H3N8 from wild birds in the study clustered with two emerged human H3N8 viruses in 2022 in the same Eurasian avian lineage.
      • The H3N8 from wild birds in the study presented dual receptors preferences.
      • The H3N8 from wild birds in the study replicated well in mammalian model without prior adaption.


      We present the phylogeny, receptor binding property, growth in mammal cells and pathogenicity in mammal model of H3N8 viruses, which were isolated from wild birds in China. The human receptor preference and efficient replication in mice without prior adaption highlight that the H3N8 virus possesses the public threat potential.


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      1. (Accessed on Jun 8th, 2022).

        • Cheng D.
        • Dong Y.
        • Wen S.
        • Shi C.
        A child with acute respiratory distress syndrome caused by avian influenza H3N8 virus.
        J Infect. 2022; 85: 174-211
      2. (Accessed on Jun 8th, 2022).

        • Toh X.
        • Soh M.L.
        • Ng M.K.
        • Yap S.C.
        • Harith N.
        • Fernandez C.J.
        • et al.
        Isolation and characterization of equine influenza virus (H3N8) from an equine influenza outbreak in Malaysia in 2015.
        Transbound Emerg Dis. 2019; 66: 1884-1893
        • Cao X.
        • Liu X.
        • Zheng S.
        • Xu L.
        • Wu H.
        • Liu J.
        Isolation and characterization of an avian-origin H3N8 canine influenza virus from a dog in eastern China.
        Arch Virol. 2018; 163: 1955-1960
        • Yang H.
        • Nguyen H.T.
        • Carney P.J.
        • Guo Z.
        • Chang J.C.
        • Jones J.
        • et al.
        Structural and functional analysis of surface proteins from an A(H3N8) influenza virus isolated from New England harbor seals.
        J Virol. 2015; 89: 2801-2812
        • Yang H.
        • Xiao Y.
        • Meng F.
        • Sun F.
        • Chen M.
        • Cheng Z.
        • et al.
        Emergence of H3N8 equine influenza virus in donkeys in China in 2017.
        Vet Microbiol. 2018; 214: 1-6
        • Cui Y.
        • Li Y.
        • Li M.
        • Zhao L.
        • Wang D.
        • Tian J.
        • et al.
        Evolution and extensive reassortment of H5 influenza viruses isolated from wild birds in China over the past decade.
        Emerg Microbes Infect. 2020; 9: 1793-1803
        • Li Y.
        • Li M.
        • Tian J.
        • Zhang Y.
        • Bai X.
        • Wang X.
        • et al.
        Characteristics of the first H16N3 subtype influenza A viruses isolated in western China.
        Transbound Emerg Dis. 2020; 67: 1677-1687