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Rapid emergence of ceftazidime-avibactam resistance among carbapenem-resistant Enterobacterales in a tertiary-care hospital in Taiwan

  • Jia-Arng Lee
    Affiliations
    Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
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  • Shin-Hei Du
    Affiliations
    Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
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  • Tai-fen Lee
    Affiliations
    Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
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  • Yu-Shan Huang
    Affiliations
    Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
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  • Chun-Hsing Liao
    Affiliations
    Colleague of Medicine, National Yang-Ming University, Taipei, Taiwan

    Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan
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  • Yu-Tsung Huang
    Correspondence
    Corresponding author at: Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
    Affiliations
    Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan

    Graduate Institute of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan
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  • Po-Ren Hsueh
    Correspondence
    Corresponding author at: Departments of Laboratory Medicine and Internal Medicine, China Medical University Hospital, School of Medicine, China Medical University, Taichung, Taiwan.
    Affiliations
    Departments of Laboratory Medicine and Internal Medicine, School of Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan

    Ph.D Program for Aging, College of Medicine, China Medical University, Taichung, Taiwan
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Published:October 15, 2022DOI:https://doi.org/10.1016/j.jinf.2022.10.003
      We read with great interest the article by Zha et al. describing a nationwide survey on the management of infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) in critically ill patients of tertiary hospitals in China.
      • Zha L.
      • Li S.
      • Ren Z.
      • Li X.
      • Zhang D.
      • Zou Y.
      • et al.
      Clinical management of infections caused by carbapenem-resistant Klebsiella pneumoniae in critically ill patients: a nationwide survey of tertiary hospitals in mainland China.
      In this study, only 16% of the participating hospitals offered ceftazidime-avibactam (CZA) for treating carbapenem-resistant K. pneumoniae infections. The authors recommended that routine detection of carbapenemases and in vitro susceptibility for CZA among all CRKP isolates are necessary, as a nationwide survey in China has demonstrated an 11.1% of CRKP isolates resistant to this agent.
      • Zha L.
      • Li S.
      • Ren Z.
      • Li X.
      • Zhang D.
      • Zou Y.
      • et al.
      Clinical management of infections caused by carbapenem-resistant Klebsiella pneumoniae in critically ill patients: a nationwide survey of tertiary hospitals in mainland China.
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