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Genetic characterization of a novel quadruple reassortant influenza A (H1N2) virus from swine, China, 2021

  • Author Footnotes
    1 These authors contributed equally to this work.
    Hailiang Sun
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China

    Key Laboratory of Zoonosis Control and Prevention of Guangdong Province, South China Agricultural University, Guangzhou 510642, China

    National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, South China Agricultural University, Guangzhou 510642, China
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Hanlin Liu
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China

    Key Laboratory of Zoonosis Control and Prevention of Guangdong Province, South China Agricultural University, Guangzhou 510642, China

    National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, South China Agricultural University, Guangzhou 510642, China
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  • Yanwei Liu
    Affiliations
    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China

    Key Laboratory of Zoonosis Control and Prevention of Guangdong Province, South China Agricultural University, Guangzhou 510642, China

    National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, South China Agricultural University, Guangzhou 510642, China
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  • Zifeng Pang
    Affiliations
    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China

    Key Laboratory of Zoonosis Control and Prevention of Guangdong Province, South China Agricultural University, Guangzhou 510642, China

    National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, South China Agricultural University, Guangzhou 510642, China
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  • Yinglin Jiang
    Affiliations
    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China

    Key Laboratory of Zoonosis Control and Prevention of Guangdong Province, South China Agricultural University, Guangzhou 510642, China

    National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, South China Agricultural University, Guangzhou 510642, China
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  • Quan Liu
    Affiliations
    Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China

    Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China
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  • Ming Liao
    Correspondence
    Corresponding author.
    Affiliations
    Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China

    Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China
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  • Author Footnotes
    1 These authors contributed equally to this work.
Published:September 10, 2022DOI:https://doi.org/10.1016/j.jinf.2022.09.009
      We read with interest a recent letter in the Journal of Infection, which reported the emergence of novel H5N6 reassortant and it's threat to both birds and humans.
      • Sun R
      • Jiang W
      • Liu S
      • Peng C
      • Yin X
      • Liu H
      • et al.
      Emergence of novel reassortant H5N6 influenza viruses in poultry and humans in Sichuan Province, China, 2021.
      Pigs are susceptible to human, swine, and avian influenza A viruses (IAVs) and considered as intermediate hosts or “mixing vessels” for generating novel viruses with pandemic potential.
      • Ma W
      • Lager KM
      • Vincent AL
      • Janke BH
      • Gramer MR
      • Richt JA.
      The role of swine in the generation of novel Influenza viruses.
      Moreover, China has a complicated ecosystem of swine influenza viruses (SIVs) in which H1N1, H1N2, and H3N2 subtypes with classical swine (CS), North America triple-reassortant (TR), Eurasian avian-like (EA), and H1N1 pandemic/2009 (pdm/09) lineages are co-circulating throughout the swine population. This co-circulation has led to frequent emergence of novel reassortments or genotypes.
      • Vijaykrishna D
      • Smith GJ
      • Pybus OG
      • Zhu H
      • Bhatt S
      • Poon LL
      • et al.
      Long-term evolution and transmission dynamics of swine influenza A virus.
      In this study, we report a novel influenza virus A(H1N2) virus, A/swine/Henan/417/2021(H1N2) (HN/21) that was isolated from a swine farm in December 12, 2021 in Henan, China.
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