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Clinical impact of next-generation sequencing on laboratory diagnosis of suspected culture-negative meningitis and encephalitis

  • Fanfan Xing
    Affiliations
    Department of Clinical Microbiology and Infection Control, The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China
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  • Qingyan Yang
    Affiliations
    Neuromedicine Center, The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China
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  • Chaowen Deng
    Affiliations
    Department of Clinical Microbiology and Infection Control, The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China
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  • Linlin Sun
    Affiliations
    Department of Clinical Microbiology and Infection Control, The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China
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  • Zhendong Luo
    Affiliations
    Department of Radiology, The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China
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  • Haiyan Ye
    Affiliations
    Department of Clinical Microbiology and Infection Control, The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China
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  • Jin Yang
    Affiliations
    Department of Clinical Microbiology and Infection Control, The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China
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  • Simon K.F. Lo
    Affiliations
    Department of Clinical Microbiology and Infection Control, The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China
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  • Susanna K.P. Lau
    Correspondence
    Corresponding author at: Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 19/F, Block T, Queen Mary Hospital Compound, Pokfulam, Hong Kong. Phone: +852-2255-2584. Fax: +852-2855-1241.
    Affiliations
    Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
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  • Patrick C.Y. Woo
    Correspondence
    Corresponding author at: PhD Program in Translational Medicine and Department of Life Sciences, National Chung Hsing University, 145 Xingda Road, South District, Taichung 402, Taiwan. Phone: +886-4-22840370 ext. 19. Fax: +886-4-22860164.
    Affiliations
    PhD Program in Translational Medicine and Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan

    The iEGG and Animal Biotechnology Research Center, National Chung Hsing University, Taichung 402, Taiwan

    Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
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Published:August 26, 2022DOI:https://doi.org/10.1016/j.jinf.2022.08.026
      We read with interest an article published by Yin et al. on the performance of metagenomics next-generation sequencing (mNGS) in sepsis
      • Yin M.
      • Zheng Y.
      • Zhang L.
      • Qin W.
      • Han H.
      • Wu D.
      • Wang H.
      The real-life performance of metagenomic next-generation sequencing in sepsis.
      . Here, we describe the clinical impact of NGS in confirming the microbiological cause and excluding an infective etiology as well as stopping unnecessary antimicrobials and adding specific treatment in patients with suspected culture-negative meningitis and encephalitis.

      Keywords

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