A genome-wide cross-trait analysis highlights the shared genetic structure between COVID-19 and Alzheimer's disease

Published:August 26, 2021DOI:https://doi.org/10.1016/j.jinf.2021.08.038
      We read with interest the recently published research in Journal of Infection by Yang et al. who reported the higher mortality of COVID-19 patients with dementia compared with COVID-19 patients without dementia (effect estimate = 1.84, 95% CI: 1.57–2.16).
      • Yang H.
      • Liang X.
      • Hou H.
      • Xu J.
      • Shi L.
      • Wang Y.
      The association of dementia with COVID-19 mortality: evidence based on adjusted effect estimates.
      Meanwhile, patients recovering from COVID-19 had a more severe burden of cognitive impairment, suggesting the potential risk of Alzheimer's disease.
      • Al-Aly Z.
      • Xie Y.
      • Bowe B.
      High-dimensional characterization of post-acute sequelae of COVID-19.
      Although growing evidences indicate the potential genetic overlap between Alzheimer's disease and COVID-19, the genetic association degree and the shared genetic structure region between the two diseases remain unknown.
      • Lim K.H.
      • Yang S.
      • Kim S.H.
      • Joo J.Y.
      Elevation of ACE2 as a SARS-CoV-2 entry receptor gene expression in Alzheimer's disease.
      In this study, we aim to clarify the following three questions: (Ⅰ) Does the genetic association exist between COVID-19 and Alzheimer's disease? (Ⅱ) Where is the shared genetic region between COVID-19 and Alzheimer's disease? (Ⅲ) Is there a causal relationship between COVID-19 and Alzheimer's disease?
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      Reference

        • Yang H.
        • Liang X.
        • Hou H.
        • Xu J.
        • Shi L.
        • Wang Y.
        The association of dementia with COVID-19 mortality: evidence based on adjusted effect estimates.
        J Infect. 2021; 82 (MayPubMed PMID: 33582205. Pubmed Central PMCID: PMC7879026. Epub 2021/02/15): e6-e10
        • Al-Aly Z.
        • Xie Y.
        • Bowe B.
        High-dimensional characterization of post-acute sequelae of COVID-19.
        Nature. 2021; 594 (JunPubMed PMID: 33887749. Epub 2021/04/23): 259-264
        • Lim K.H.
        • Yang S.
        • Kim S.H.
        • Joo J.Y.
        Elevation of ACE2 as a SARS-CoV-2 entry receptor gene expression in Alzheimer's disease.
        J Infect. 2020; 81 (Sepe33-e4. PubMed PMID: 32619698. Pubmed Central PMCID: PMC7834154. Epub 2020/07/04)
        • Initiative C.H.G.
        Mapping the human genetic architecture of COVID-19.
        Nature. 2021; (Jul 8PubMed PMID: 34237774. Epub 2021/07/09, https://www.nature.com/articles/s41586-021-03767-x)
        • Kunkle B.W.
        • Grenier-Boley B.
        • Sims R.
        • Bis J.C.
        • Damotte V.
        • Naj A.C.
        • et al.
        Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates abeta, tau, immunity and lipid processing.
        Nat Genet. 2019; 51 (MarPubMed PMID: 30820047. Pubmed Central PMCID: PMC6463297. Epub 2019/03/02): 414-430
        • Bulik-Sullivan B.
        • Finucane H.K.
        • Anttila V.
        • Gusev A.
        • Day F.R.
        • Loh P.R.
        • et al.
        An atlas of genetic correlations across human diseases and traits.
        Nat Genet. 2015; 47 (NovPubMed PMID: 26414676. Pubmed Central PMCID: PMC4797329. Epub 2015/09/29): 1236-1241
        • Shaath H.
        • Vishnubalaji R.
        • Elkord E.
        • Alajez N.M.
        Single-cell transcriptome analysis highlights a role for neutrophils and inflammatory macrophages in the pathogenesis of severe COVID-19.
        Cells. 2020; 9 (Oct 29PubMed PMID: 33138195. Pubmed Central PMCID: PMC7693119. Epub 2020/11/04)2374
        • Wang C.
        • Zhang M.
        • Garcia G.
        • Tian E.
        • Cui Q.
        • Chen X.
        • et al.
        ApoE-isoform-dependent SARS-CoV-2 neurotropism and cellular response.
        Cell Stem Cell. 2021; 28 (Feb 4e5. PubMed PMID: 33450186. Pubmed Central PMCID: PMC7832490. Epub 2021/01/16): 331-342
        • Hemani G.
        • Zheng J.
        • Elsworth B.
        • Wade K.H.
        • Haberland V.
        • Baird D.
        • et al.
        The MR-base platform supports systematic causal inference across the human phenome.
        Elife. 2018; 7 (May 30PubMed PMID: 29846171. Pubmed Central PMCID: PMC5976434. Epub 2018/05/31)e34408