- •Low serum levels of H2S in COVID-19 pneumonia are associated with a poor prognosis.
- •Endogenous H2S production can be increased therapeutically by administering NAC.
- •NAC therapy was associated with improvement in SpO2/FiO2, CRP, and NEWS2 scale.
- •There were no significant differences in the clinical outcomes (IMV, mortality).
- •NAC therapy was not associated with moderate and severe adverse events.
- Dexamethasone in hospitalized patients with COVID-19.N Engl J Med. 2021; 384: 693-704https://doi.org/10.1056/NEJMoa2021436
- Tocilizumab in patients admitted to hospital with COVID-19 (recovery): a randomised, controlled, open-label, platform trial.Lancet. 2021; 397: 1637-1645https://doi.org/10.1016/S0140-6736(21)00676-0
- Secukinumab in severe COVID-19 pneumonia: does it have a clinical impact?.J Infect. 2021; 83: e11-e13https://doi.org/10.1016/j.jinf.2021.05.011
- N-Acetylcysteine and hydrogen sulfide in Coronavirus disease 2019.Antioxid Redox Signal. 2021; https://doi.org/10.1089/ars.2020.8247
- Serum hydrogen sulfide and outcome association in pneumonia by the SARS-CoV-2 coronavirus.Shock. 2020; 54: 633-637https://doi.org/10.1097/SHK.0000000000001562
- Intravenous N-acetylcysteine and lung glutathione of patients with pulmonary fibrosis and normals.Am J Respir Crit Care Med. 1995; 152: 1055-1060https://doi.org/10.1164/ajrccm.152.3.7663783
- N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why.Free Radic Res. 2018; 52: 751-762https://doi.org/10.1080/10715762.2018.1468564
- Therapeutic blockade of inflammation in severe COVID-19 infection with intravenous N-acetylcysteine.Clin Immunol. 2020; 219108544https://doi.org/10.1016/j.clim.2020.108544
- Application of methylene blue -vitamin C -N-acetyl cysteine for treatment of critically ill COVID-19 patients, report of a phase-I clinical trial.Eur J Pharmacol. 2020; 885173494https://doi.org/10.1016/j.ejphar.2020.173494
- Double-blind, randomized, placebo-controlled trial with N-acetylcysteine for treatment of severe acute respiratory syndrome caused by COVID-19.Clin Infect Dis. 2021; 72: e736-e741https://doi.org/10.1093/cid/ciaa1443