Recent correspondence in this Journal has highlighted that HIV-1 frequent intersubtype
recombinants lead to its rapid evolution, extraordinary genetic variability and vast
genetic diversity.
1
By the end of April 2021, 117 circulating recombinant form (CRFs) and a large number
of unique recombinant forms (URFs) have been very well documented worldwide.
2
In China, CRF07_BC and CRF08_BC are the first prevalent intersubtype recombinants
consisting of subtype B and C among intravenous drug users (IDUs) in Yunnanprovince,
3
which located in the areas on the China-Myanmar border, and was regarded as the “hotspots”
for new HIV-1 recombination occurrence.
4
,5
Over the past three decades, numerous newly CRF_BC recombinants have been identified
in Yunnan, such as CRF57_BC, CRF62_BC, CRF64_BC, CRF86_BC, CRF88_BC, and our recently
reported CRF110_BC.
6
These findings demonstrated that the high frequency of multiple intersubtype recombinant
events between B and C were substantial and ongoing in here. In this study, we characterized
a newly emerging HIV-1 CRF118_BC comprising subtype B and C in Yunnan, and analyzed
its evolutionary history.To read this article in full you will need to make a payment
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References
- Identification of a novel HIV-1 s-generation circulating recombinant form CRF109_0107 in China.J Infect. 2020; 81: 816-846
https:www.hiv.lanl.gov/components/sequence/HIV/search/search.html.
- Burmese injecting drug users in Yunnan play a pivotal role in the cross-border transmission of HIV-1 in the China-Myanmar border region.Virulence. 2018; 9: 1195-1204
- First description of two new HIV-1 recombinant forms CRF82_cpx and CRF83_cpx among drug users in Northern Myanmar.Virulence. 2017; 8: 497-503
- A newly emerging HIV-1 circulating recombinant form (CRF110_BC) comprising subtype B and C among intravenous drug users in Yunnan, China.J Infect. 2021; 82: e8-e10
- HIV-1 CRF_BC recombinants infection in China: molecular epidemic and characterizations.Curr HIV Res. 2012; 10: 151-161
- Geographic origin and evolutionary history of China's two predominant HIV-1 circulating recombinant forms, CRF07_BC and CRF08_BC.Sci Rep. 2016; 6: 19279
- The changes of positive selection within env Gene of HIV-1 B', CRF07_BC and CRF08_BC from China over time.Curr HIV Res. 2017; 15: 31-37
- High prevalence of HIV-1 intersubtype B'/C recombinants among injecting drug users in Dehong, China.PLoS ONE. 2013; 8: e65337
Article info
Publication history
Published online: May 16, 2021
Accepted:
May 8,
2021
Identification
Copyright
© 2021 Published by Elsevier Ltd on behalf of The British Infection Association.
