Lymphocyte subset (CD4+, CD8+) counts reflect the severity of infection and predict the clinical outcomes in patients with COVID-19

Published:April 11, 2020DOI:https://doi.org/10.1016/j.jinf.2020.03.054
      We read with interest the recent article by Chen et al., which found lower CD4+ T cells count was associated with ICU admission in patients with the coronavirus disease 2019 (COVID-19).

      Chen J., Qi T., Liu L., Ling Y., Qian Z., Li T., et al. Clinical progression of patients with COVID-19 in Shanghai, China. J Infect

      Among the clinical and laboratory features of COVID-19, a number of abnormalities have been observed and described, the most prominent of which is total lymphopenia. Through routine blood analysis, a significant reduction in lymphocytes is frequently observed; however, there still lacks thoroughly research about the lymphocyte subset counts. Here, we aimed to investigate the changes of lymphocyte subset counts in COVID-19 patients and determine if these changes are associated with disease severity and prognosis.

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      References

      1. Chen J., Qi T., Liu L., Ling Y., Qian Z., Li T., et al. Clinical progression of patients with COVID-19 in Shanghai, China. J Infect

      2. National Health Commission of the People’s Republic of China. Guidelines for the Diagnosis and Treatment of COVID-19 (Trial Version 6) 2020. Available from: http://www.gov.cn/zhengce/zhengceku/2020-02/19/content_5480948.htm.

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