Highlights
- •Consensus view from Public Health England's HCV Resistance Group.
- •Review providing guidance on when and how to perform HCV resistance testing, and interpretation of results.
- •Includes five key scenarios where HCV resistance testing is recommended in the UK and other similar settings.
Abstract
The treatment of hepatitis C virus (HCV) infection has been revolutionised by the
advent of oral, well-tolerated, direct acting antiviral therapies (DAA), with high
cure rates. However, in some scenarios, HCV resistance to antiviral therapies may
have an impact on treatment success. Public Health England's HCV Resistance Group
was established to support clinicians treating people with HCV, where the issue of
resistance may be a factor in clinical decision-making, and this review includes the
Group's current recommendations on the use of HCV resistance testing. The authors
describe the principles behind and approach to HCV resistance testing and consider
evidence from in vitro studies, clinical trials and real world cohorts on the impact of HCV resistance on
treatment outcomes for particular DAA regimens. Five scenarios are identified in the
UK and similar settings, where, in the Group's opinion, resistance testing should
be performed.
Keywords
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Article info
Publication history
Published online: October 16, 2019
Accepted:
October 13,
2019
Identification
Copyright
Crown Copyright © 2019 Published by Elsevier Ltd on behalf of The British Infection Association. All rights reserved.
