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Letter to the Editor| Volume 78, ISSUE 6, P491-503, June 2019

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Human-isolated H7N9 obtained internal genes from duck and human influenza viruses

  • Zhiqing Pu
    Affiliations
    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
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  • Jinjin Yang
    Affiliations
    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
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  • Xuejuan Shen
    Affiliations
    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
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  • David M. Irwin
    Affiliations
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5S 1A8, Canada

    Banting and Best Diabetes Centre, University of Toronto, Toronto M5S 1A8, Canada
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  • Yongyi Shen
    Correspondence
    Corresponding author at: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
    Affiliations
    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China

    Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, South China Agricultural University, Guangzhou 510642, China

    Shantou University Medical College, Shantou 515041, China
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Published:March 14, 2019DOI:https://doi.org/10.1016/j.jinf.2019.03.008
Human-isolated H7N9 obtained internal genes from duck and human influenza viruses
Previous ArticleRapid evolution and gene communication of H3N2 and H1N1 influenza a viruses
Next ArticlePoor transmission of seasonal cold viruses in a British Antarctic Survey base
      Recent studies in this journal revealed that some H7N9 viruses reassorted with duck AIVs, and then attained the ability to efficiently infect ducks.
      • Hou G.
      • Li J.
      • Wang S.
      • Cheng S.
      • Peng C.
      • Chen J.
      • et al.
      Hemagglutinin characteristics, changes in pathogenicity, and antigenic variation of highly pathogenic H7N9 avian influenza viruses in China.
      J Infect. 2019; 78: 158-169
      , 
      • He L.
      • Liu D.
      • Hu J.
      • Shi L.
      • Liu J.
      • Cai T.
      • et al.
      Two novel reassortant high pathogenic H7N9 viruses isolated in Southern China in fifth wave shows internal genomic diversity and high virulence in chickens and ducks.
      J Infect. 2018; 77: 561-571
      H7N9 AIVs have been endemic in chicken since their emergence in China in February 2013.
      • Gao R.
      • Cao B.
      • Hu Y.
      • Feng Z.
      • Wang D.
      • Hu W.
      • et al.
      Human infection with a novel avian-origin influenza A (H7N9) virus.
      N Engl J Med. 2013; 368: 1888-1897
      After its emergence, H7N9 viruses have evolved substantially, and have frequently reassorted, acquiring internal genes from other chicken H9N2 viruses, increasing the genetic diversity of H7N9 viruses.
      • Xiang D.
      • Pu Z.
      • Luo T.
      • Guo F.
      • Li X.
      • Shen X.
      • et al.
      Evolutionary dynamics of avian influenza A H7N9 virus across five waves in mainland China, 2013–2017.
      J Infect. 2018; 77: 205-211
      This raises the concern that whether H7N9 can attain internal genes from other AIVs. Thus, we collected all available H7N9 sequences to detect potential novel reassortments of the H7N9 AIVs, and found evidences that three human-isolated H7N9 isolates attained internal genes from duck and human AIVs.
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        • et al.
        Hemagglutinin characteristics, changes in pathogenicity, and antigenic variation of highly pathogenic H7N9 avian influenza viruses in China.
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        View in Article
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      Article info

      Publication history

      Published online: March 14, 2019
      Accepted: March 12, 2019

      Identification

      DOI: https://doi.org/10.1016/j.jinf.2019.03.008

      Copyright

      © 2019 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

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