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Letter to the Editor| Volume 78, ISSUE 6, P491-503, June 2019

First experience of ribavirin postexposure prophylaxis for Nipah virus, tried during the 2018 outbreak in Kerala, India

Published:March 06, 2019DOI:https://doi.org/10.1016/j.jinf.2019.03.005
      We read with interest, the article by Poller et al.
      • Poller B.
      • Tunbridge A.
      • Hall S.
      • Beadsworth M.
      • Jacobs M.
      • Peters E.
      • et al.
      A unified personal protective equipment ensemble for clinical response to possible high consequence infectious diseases: a consensus document on behalf of the HCID programme.
      , in this journal, entitled “A unified personal protective equipment….”. We understand the importance of proper personal protective equipment(PPE) as an integral component of healthcare workers(HCW) protection in outbreak situations of infections with possible high consequence. But at times, such an outbreak occurs in an unsuspected region, when initial cases present in early course of illness before the development of ominous clinical features. Medical staff, particularly in busy rural set ups of resource-poor developing countries may discover that they have been exposed to a high consequence infectious disease after the event of exposure, particularly if these centres are unaware, reluctant or unequipped regarding routine use of PPE. A similar situation occurred in a rural healthcare setting of Kerala, India, during the May-2018 outbreak of Nipah virus (NiV), killing 21 out of 23 reported cases.
      • Arunkumar G.
      • Chandni R.
      • Mourya D.T.
      • Singh S.K.
      • Sadanandan R.
      • Sudan P.
      • et al.
      Outbreak investigation of Nipah virus disease in Kerala, India, 2018.
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      References

        • Poller B.
        • Tunbridge A.
        • Hall S.
        • Beadsworth M.
        • Jacobs M.
        • Peters E.
        • et al.
        A unified personal protective equipment ensemble for clinical response to possible high consequence infectious diseases: a consensus document on behalf of the HCID programme.
        J Infect. 2018; 77: 496-502https://doi.org/10.1016/j.jinf.2018.08.016
        • Arunkumar G.
        • Chandni R.
        • Mourya D.T.
        • Singh S.K.
        • Sadanandan R.
        • Sudan P.
        • et al.
        Outbreak investigation of Nipah virus disease in Kerala, India, 2018.
        J Infect Dis. 2018; https://doi.org/10.1093/infdis/jiy612
        • Chadha Mandeep S.
        • Comer James A.
        • Luis Lowe
        • Rota Paul A.
        • Rollin Pierre E.
        • Bellini William J.
        • et al.
        Nipah virus-associated encephalitis outbreak, Siliguri, India.
        Emerging Infect Dis. 2006; 12: 235-240https://doi.org/10.3201/eid1202.051247
        • Hassan Md Zakiul
        • Sazzad H.M.S.
        • Luby S.P.
        • Sturm-Ramirez K.
        • Bhuiyan M.U.
        • Rahman M.Z.
        • et al.
        Nipah virus contamination of hospital surfaces during outbreaks, Bangladesh, 2013–2014.
        Emerging Infect Dis. 2018; 24: 15-21https://doi.org/10.3201/eid2401.161758
        • Aljofan M.
        • Saubern S.
        • Meyer A.G.
        • Marsh G.
        • Meers J.
        • Mungall B.A.
        Characteristics of Nipah virus and Hendra virus replication in different cell lines and their suitability for antiviral screening.
        Virus Res. 2009; 142: 92-99https://doi.org/10.1016/j.virusres.2009.01.014
        • Chong H.T.
        • Kamarulzaman A.
        • Tan C.T.
        • Goh K.J.
        • Thayaparan T.
        • Kunjapan S.R.
        • et al.
        Treatment of acute Nipah encephalitis with ribavirin.
        Ann Neurol. 2001; 49: 810-813
        • Bausch Daniel G.
        • Hadi Christiane M.
        • Khan Sheik Humarr
        • Lertora Juan J.L.
        Review of the literature and proposed guidelines for the use of oral ribavirin as postexposure prophylaxis for Lassa fever.
        Clin Infect Dis. 2010; 51: 1435-1441https://doi.org/10.1086/657315
        • Savini H.
        • Ficko C.
        • Simon F.
        Post-exposure prophylaxis in Ebola virus disease: don't forget the psychological factors.
        Lancet Infect Dis. 2018; 18: 378https://doi.org/10.1016/S1473-3099(18)30131-2
        • Arunkumar G.
        • Devadiga S.
        • McElroy A.K.
        • Prabhu S.
        • Sheik S.
        • Abdulmajeed J.
        • et al.
        Adaptive immune responses in humans during Nipah virus acute and convalescent phases of infection.
        Clin Infect Dis. 2019; https://doi.org/10.1093/cid/ciz010
        • Mourya D.T.
        • Yadav P.
        • Sudeep A.B.
        • Gokhale M.D.
        • Gupta N.
        • Gangakhedkar R.R.
        • et al.
        A spatial association between a Nipah virus outbreak in Kozhikode, Kerala, India and Nipah virus infection in Pteropus bats.
        Clin Infect Dis. 2018; https://doi.org/10.1093/cid/ciy1093