Highlights
- •Novel methodology using linked data to estimate the hospital burden of RSV.
- •Detailed estimates of RSV-associated admissions and bed days in infants in England.
- •RSV-associated admissions peaked in infants aged 6 weeks.
- •RSV-associated admissions peaked in infants born September to November.
Summary
Objectives
Current national estimates of respiratory syncytial virus (RSV)-associated hospital
admissions are insufficiently detailed to determine optimal vaccination strategies
for RSV. We employ novel methodology to estimate the burden of RSV-associated hospital
admissions in infants in England, with detailed stratification by patient and clinical
characteristics.
Methods
We used linked, routinely collected laboratory and hospital data to identify laboratory-confirmed
RSV-positive and RSV-negative respiratory hospital admissions in infants in England,
then generate a predictive logistic regression model for RSV-associated admissions.
We applied this model to all respiratory hospital admissions in infants in England,
to estimate the national burden of RSV-associated admissions by calendar week, age
in weeks and months, clinical risk group and birth month.
Results
We estimated an annual average of 20,359 (95% CI 19,236-22,028) RSV-associated admissions
in infants in England from mid-2010 to mid-2012. These admissions accounted for 57,907
(95% CI 55,391-61,637) annual bed days. 55% of RSV-associated bed days and 45% of
RSV-associated admissions were in infants <3 months old. RSV-associated admissions
peaked in infants aged 6 weeks, and those born September to November.
Conclusions
We employed novel methodology using linked datasets to produce detailed estimates
of RSV-associated admissions in infants. Our results provide essential baseline epidemiological
data to inform future vaccine policy.
Keywords
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Article info
Publication history
Published online: February 25, 2019
Accepted:
February 18,
2019
Identification
Copyright
© 2019 Published by Elsevier Ltd on behalf of The British Infection Association.
