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Reversion of QuantiFERON-TB Gold In-Tube test in individuals with and without prophylactic treatment for latent tuberculosis infection: A systematic review and meta-analysis

  • Author Footnotes
    1 Both authors contributed equally to this work.
    Haoran Zhang
    Footnotes
    1 Both authors contributed equally to this work.
    Affiliations
    MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Centre for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
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  • Author Footnotes
    1 Both authors contributed equally to this work.
    Henan Xin
    Footnotes
    1 Both authors contributed equally to this work.
    Affiliations
    MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Centre for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Search for articles by this author
  • Xiangwei Li
    Affiliations
    MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Centre for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
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  • Hengjing Li
    Affiliations
    MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Centre for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Search for articles by this author
  • Mufei Li
    Affiliations
    MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Centre for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
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  • Boxuan Feng
    Affiliations
    MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Centre for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
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  • Lei Gao
    Correspondence
    Corresponding author.
    Affiliations
    MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Centre for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Search for articles by this author
  • Author Footnotes
    1 Both authors contributed equally to this work.

      Highlights

      • QFT reversion was frequently observed in serial tests.
      • Summarized QFT reversion rates were found to be similar among individuals with and without preventive treatment.
      • Serial QFT testing might be inappropriate for evaluating preventive treatment efficacy.

      Summary

      Objectives

      Reversion of tuberculosis (TB) infection testing has been suggested to be associated with prophylactic treatment efficacy. However, evidences based on randomized controlled study were sparse.

      Methods

      Studies on serial QuantiFERON-TB Gold In-Tube (QFT) test, among individuals with and without prophylactic treatment were identified in the databases of PubMed, MEDLINE and EMBASE up to 28 February 2018. The reversion rates were quantitatively summarized by means of meta-analysis using the random-effect model.

      Results

      A total of 52 eligible studies were included in the meta-analysis on QFT test reversion rate among participants with (20 studies) and without (32 studies) prophylactic treatment. Summarized reversion rate was found to be 24.9% (95% confidence interval [CI]: 18.4–32.9%) and 25.3% (95% CI: 19.6–32.0%) for those completed or without treatment, respectively. When the analysis was restricted to the participants completed treatment, higher summarized rate of QFT reversion was found among those with longer course therapy (9INH vs. the other regimens), studies from Asia (vs. Europe and America), and individuals with immunosuppression disorders (vs. general populations).

      Conclusions

      Our results suggested that QFT reversion was frequently observed regardless of with or without prophylactic treatment. Serial QFT testing might be inappropriate for evaluating preventive treatment efficacy.

      Keywords

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