Highlights
- •Candida auris is now present in the American continent.
- •C. auris is a multiresistant pathogen able to cause nosocomial outbreaks in pediatric and adult patients exposed to antibiotics and multiple invasive medical procedures.
- •Mortality rates of C. auris fungemia is lower in pediatric population than in adults.
Summary
Objectives
Characterization of a hospital outbreak of Candida auris candidemia that involved 18 critically ill patients in Venezuela.
Method
Bloodstream isolates of C. auris obtained from 18 patients admitted at a medical center in Maracaibo, between March,
2012 and July, 2013 were included. Species identification was confirmed by ITS rDNA
sequencing. Isolates were subsequently typed by amplified fragment length polymorphism
fingerprinting (AFLP). Susceptibility testing was performed according to CLSI. Clinical
data were collected from all cases by using a standard clinical form.
Results
A total of 13 critically ill pediatric and 5 adult patients, with a median age of
26 days, were included. All were previously exposed to antibiotics and multiple invasive
medical procedures. Clinical management included prompt catheter removal and antifungal
therapy. Thirteen patients (72%) survived up to 30 days after onset of candidemia.
AFLP fingerprinting of all C. auris isolates suggested a clonal outbreak. The isolates were considered resistant to azoles,
but susceptible to anidulafungin and 50% of isolates exhibited amphotericin B MIC
values of >1 μg/ml.
Conclusions
The study demonstrated that C. auris is a multiresistant yeast pathogen that can be a source of health-care associated
infections in tertiary care hospitals with a high potential for nosocomial horizontal
transmission.
Keywords
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Article info
Publication history
Published online: July 21, 2016
Accepted:
July 9,
2016
Identification
Copyright
© 2016 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
