Summary
Objective
To examine the prevalence and distribution among racial/ethnic groups of polyomavirus
SV40 antibodies in women in Houston, Texas.
Methods
Women in three different cohorts reflecting the evolving demographics of Houston were
evaluated for frequency of SV40 antibodies using a plaque-reduction neutralization
assay.
Results
Women in cohort A (enrolled 1972–1973) were 68% (145/212) African-American and 32%
Caucasian; the overall frequency of SV40 neutralizing antibodies was 7%. Women in
cohort B (enrolled 1975–1977) were Caucasian with an overall frequency of SV40 neutralizing
antibodies of 18% (37/211). Women in cohort C (enrolled 1993–1995) were 50% (199/400)
African-American, 25% Caucasian, and 25% Hispanic; the overall frequency of SV40 neutralizing
antibodies was 10%. Logistic regression analysis for cohort A showed no difference
in SV40 neutralizing antibodies with respect to race/ethnicity, pregnancy status,
number of previous pregnancies, or history of sexually transmitted diseases. For cohort
C, race/ethnicity was identified as a significant factor associated with SV40 neutralizing
antibodies, with Hispanics having a seroprevalence of 23% compared to 5–6% in the
other two groups (p = 0.01).
Conclusions
A significantly higher SV40 seroprevalence was found among Hispanics than other racial/ethnic
groups in the city of Houston. Findings are compatible with a model that certain population
groups potentially exposed to SV40-contaminated oral poliovaccines have maintained
cycles of SV40 infections.
Keywords
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References
- Virus taxonomy.(Ninth Report of the International Committee on Taxonomy of Viruses) Academic Press, San Diego2012
- Virology division, international union of microbiological societies.2012
- Human exposure to SV40: review and comment.Am J Epidemiol. 1976; 103: 1-12
- Polyomavirus SV40: model infectious agent of cancer.in: Robertson E. Cancer associated viruses. Springer Science, 2012: 377-417
- Patterns of polyomavirus SV40 infections and associated cancers in humans: a model.Curr Opin Virol. 2012; 2: 508-514
- Immunization safety review: SV40 contamination of polio vaccine and cancer.The National Academies Press, Washington, DC2003
- Emergent human pathogen simian virus 40 and its role in cancer.Clin Microbiol Rev. 2004; 17: 495-508
- Conventional epidemiology and the link between SV40 and human cancers.Lancet Oncol. 2003; 4: 188-191
- An evaluation of the carcinogenicity of simian virus 40 in man.J Am Med Assoc. 1963; 185: 85-90
Pan American Sanitary Bureau. First International Conference on Live Poliovirus Vaccines (Washington, D.C., 22–26 June 1959). Papers Presented and Discussions Held. Washington, D.C.: Pan American Sanitary Bureau, Scientific Publication No. 44; 1959.
Pan American Sanitary Bureau. Second International Conference on Live Poliovirus Vaccines (Washington, D.C., 6–10 June 1960). Papers Presented and Discussions Held. Washington, D.C.: Pan American Sanitary Bureau, Scientific Publication No. 50; 1960.
- Simian virus 40, human infections, and cancer: emerging concepts and causality considerations.in: Khalili K. Jeang K.T. Viral oncology: basic science and clinical applications. Wiley-Blackwell, Hoboken, NJ2010: 165-189
- Polyomavirus SV40 infections in Kazakhstan.J Infect. 2005; 50: 142-148
- Detection of antibodies to polyomavirus SV40 in two central European countries.Cent Eur J Public Health. 2003; 11: 3-8
- Studies of neutralising antibodies to SV40 in human sera.J Med Virol. 2003; 70: 490-495
- Lymphoproliferative disorders in Costa Rica and simian virus 40.Haematologica. 2005; 90: 1635-1642
- Serological cross-reactivities between antibodies to simian virus 40, BK virus, and JC virus assessed by virus-like-particle-based enzyme immunoassays.Clin Diagn Lab Immunol. 2003; 10: 278-285
- Simian virus 40 (SV40) and human cancer: a review of the serological data.Rev Med Virol. 2004; 14: 231-239
- Seroepidemiology of human polyomaviruses.PLoS Pathog. 2009; 5: e1000363
- Evidence of SV40 infections in hospitalized children.Hum Pathol. 1999; 30: 1496-1502
- Serum antibodies to JC virus, BK virus, simian virus 40, and the risk of incident adult astrocytic brain tumors.Cancer Epidemiol Biomark Prev. 2003; 12: 460-463
- Serological evidence of SV40 infections in HIV-infected and HIV-negative adults.J Med Virol. 1998; 54: 276-284
- Specific antibodies reacting with simian virus 40 capsid protein mimotopes in serum samples from healthy blood donors.Hum Immunol. 2012; 73: 502-510
- Preface.in: Khalili K. Stoner G.L. Human polyomaviruses: molecular and clinical perspectives. Wiley-Liss, Inc., New York2001: xi-xii
- Hsiung's diagnostic virology.4th ed. Yale University Press, New Haven1994
- Frequent detection of polyomaviruses in stool samples from hospitalized children.J Infect Dis. 2005; 192: 658-664
- High frequency of polyoma BK virus shedding in the gastrointestinal tract after hematopoietic stem cell transplantation: a prospective and quantitative analysis.Bone Marrow Transplant. 2009; 43: 43-47
- Polyomavirus shedding in the stool of healthy adults.J Clin Microbiol. 2009; 47: 2388-2391
- Detection of BK, JC, WU, or KI polyomaviruses in faecal, urine, blood, cerebrospinal fluid and respiratory samples.J Clin Virol. 2009; 45: 249-254
- Excretion of the novel polyomaviruses KI and WU in the stool of patients with hematological disorders.J Med Virol. 2009; 81: 1668-1673
- Potential transmission of human polyomaviruses through the gastrointestinal tract after exposure to virions or viral DNA.J Virol. 2001; 75: 10290-10299
- Detection of human-derived fecal pollution in environmental waters by use of a PCR-based human polyomavirus assay.Appl Environ Microbiol. 2006; 72: 7567-7574
- Newly described human polyomaviruses Merkel cell, KI and WU are present in urban sewage and may represent potential environmental contaminants.Virol J. 2010; 7: e141
- Excretion of vacuolating SV-40 virus (papova virus group) after ingestion as a contaminant of oral poliovaccine.Proc Soc Exp Biol Med. 1962; 109: 965-968
- Viral regulatory region effects on vertical transmission of polyomavirus SV40 in hamsters.Virology. 2009; 386: 94-101
- SV40 early region and large T antigen in human brain tumors, peripheral blood cells, and sperm fluids from healthy individuals.Cancer Res. 1996; 56: 4820-4825
- High incidence of SV40-like sequences detection in tumour and peripheral blood cells of Japanese osteosarcoma patients.Br J Cancer. 2000; 82: 1677-1681
- Simian virus 40 is present in human lymphomas and normal blood.Cancer Lett. 2001; 162: 57-64
- Molecular identification of SV40 infection in human subjects and possible association with kidney disease.J Am Soc Nephrol. 2002; 13: 2320-2330
- Different simian virus 40 genomic regions and sequences homologous with SV40 large T antigen in DNA of human brain and bone tumors and of leukocytes from blood donors.Cancer. 2002; 94: 1037-1048
- Simian virus 40 sequences in malignant lymphomas in Japan.Cancer Res. 2003; 63: 7606-7608
- Molecular identification of simian virus 40 infection in healthy Italian subjects by birth cohort.Mol Med. 2005; 11: 48-51
- Evaluation of simian virus-40 as a biological prognostic factor in Egyptian patients with malignant pleural mesothelioma.Pathol Int. 2007; 57: 493-501
- Evaluation of SV40 in osteosarcoma and healthy population: a Hungarian–German study.Oncol Rep. 2009; 21: 289-297
- Detection of SV40 in blood samples from healthy subjects in the Russian federation by RT-PCR.Vestn Ross Akad Med Nauk. 2009; ([Article in Russian]): 7-10
- Simian virus 40 sequences in blood specimens from healthy individuals of Casale Monferrato, an industrial town with a history of asbestos pollution.J Infect. 2009; 58: 53-60
- Seroepidemiologic studies of herpesvirus type 2 and carcinoma of the cervix. III. Houston, Texas.Am J Epidemiol. 1973; 96: 427-442
- Design and preliminary observations of national cooperative diethylstilbestrol adenosis (DESAD) project.Obstet Gynecol. 1978; 51: 453-458
- Adverse health outcomes in women exposed in utero to diethylstilbestrol.N Engl J Med. 2011; 365: 1304-1314
- Relevance of human papillomavirus screening in management of cervical intraepithelial neoplasia.Am J Obstet Gynecol. 1997; 176: 87-92
- 2010 census profile.2012
- SV40 and human cancer: a review of recent data.Int J Cancer. 2006; 120: 215-223
- Viral and serological studies in children immunized with live poliovirus vaccine—preliminary report of a large trial conducted in Mexico.(First International Conference on Live Poliovirus Vaccines. Papers presented and Discussions Held) Pan American Sanitary Bureau, Washington, DC1959 (Scientific Publication No. 44, p. 483–496)
- Poliomyelitis vaccination with Sabin oral vaccine in Mexico City and six precincts of the Federal District.(First International Conference on Live Poliovirus Vaccines. Papers Presented and Discussions Held) Pan American Sanitary Bureau, Washington, DC1959 (Scientific Publication No. 44, p. 622–637)
- Use of Sabin's live poliovirus vaccine in Mexico. Results of a large-scale trial.(Second International Conference on Live Poliovirus Vaccines. Papers Presented and Discussions Held) Pan American Health Organization, Washington, DC1960 (Scientific Publication No. 50, p. 386–412)
- Vaccination with attenuated polioviruses in Costa Rica. Second progress report. Section I. Vaccination program.(Second International Conference on Live Poliovirus Vaccines. Papers Presented and Discussions Held) Pan American Health Organization, Washington, DC1960 (Scientific Publication No. 50, p. 561–568)
- Vaccination and challenge—poliomyelitis in Nicaragua, 1959–1960.(Second International Conference on Live Poliovirus Vaccines. Papers Presented and Discussions Held) Pan American Health Organization, Washington, DC1960 (Scientific Publication No. 50, p. 547–560)
- A história da poliomielite no Brasil e seu controle por imunização.História, Ciências, Saúde – Manguinhos. 2003; 10: 573-600
- Variable frequency of polyomavirus SV40 and herpesvirus EBV in lymphomas from two different urban population groups in Houston, TX.J Clin Virol. 2009; 46: 154-160
- Simian virus 40 tumor antigen expression and immunophenotypic profile of AIDS-related non-Hodgkin's lymphoma.Virology. 2005; 342: 38-46
- A review of cancer in U.S. Hispanic populations.Cancer Prev Res. 2012; 5: 150-163
Article info
Publication history
Published online: September 03, 2012
Accepted:
August 23,
2012
Identification
Copyright
© 2012 The British Infection Association. Published by Elsevier Inc. All rights reserved.
