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Unexpected severity of cases of influenza B infection in patients that required hospitalization during the first postpandemic wave

  • Author Footnotes
    c Both authors contributed equally to this work.
    A. Gutiérrez-Pizarraya
    Footnotes
    c Both authors contributed equally to this work.
    Affiliations
    Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain

    Member of the Spanish Network for Research in Infectious Diseases (REIPI), Spain
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  • Author Footnotes
    c Both authors contributed equally to this work.
    P. Pérez-Romero
    Footnotes
    c Both authors contributed equally to this work.
    Affiliations
    Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain

    Member of the Spanish Network for Research in Infectious Diseases (REIPI), Spain
    Search for articles by this author
  • R. Alvarez
    Affiliations
    Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain
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  • T.A. Aydillo
    Affiliations
    Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain

    Member of the Spanish Network for Research in Infectious Diseases (REIPI), Spain
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  • G. Osorio-Gómez
    Affiliations
    Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain
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  • C. Milara-Ibáñez
    Affiliations
    Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain
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  • M. Sánchez
    Affiliations
    Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain

    Member of the Spanish Network for Research in Infectious Diseases (REIPI), Spain
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  • J. Pachón
    Correspondence
    Corresponding authors. Unit of Infectious Disease, Microbiology, and Preventive Medicine, University Hospital Virgen del Rocio, Avda Manuel Siurot s/n, 41013 Sevilla, Spain. Tel.: +34 955013281; fax: +34 955013292.
    Affiliations
    Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain

    Member of the Spanish Network for Research in Infectious Diseases (REIPI), Spain
    Search for articles by this author
  • E. Cordero
    Correspondence
    Corresponding authors. Unit of Infectious Disease, Microbiology, and Preventive Medicine, University Hospital Virgen del Rocio, Avda Manuel Siurot s/n, 41013 Sevilla, Spain. Tel.: +34 955013281; fax: +34 955013292.
    Affiliations
    Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain

    Member of the Spanish Network for Research in Infectious Diseases (REIPI), Spain
    Search for articles by this author
  • Author Footnotes
    c Both authors contributed equally to this work.

      Summary

      Objectives

      After the last pandemic the knowledge regarding influenza A infection has improved however, the outcomes of influenza B infection remain poorly studied. The aim of this study was to compare the features of influenza B versus influenza A(H1N1)pdm09 infections during the 2010–2011 epidemic-season.

      Methods

      A prospective, observational-cohort of adults with laboratory-confirmed influenza infection during the 2010–2011 epidemic-season was studied

      Results

      Fifty cases of influenza B and 80 of influenza A(H1N1)pdm09 infection were enrolled. Among patients with influenza B, the median age was 34 years-old (23–64), 30% pregnant, 24% obese, 34% transplant recipients and 14% with bacterial co-infection. Twenty-eight percent of patients had pneumonia with alveolar localized pattern and five (10%) died. Pneumonia was associated with delayed antiviral therapy, older age, higher Charlson score, invasive mechanical ventilation and bacterial co-infection. Obesity and pregnancy were not associated with complicated influenza B infection. The proportion of pneumonia, admission to the ICU and mortality did not differ between cases of influenza A(H1N1)pdm09 and influenza B infection.

      Conclusions

      Influenza B infection causes severe infection and it is associated with pneumonia or death, similar to influenza A(H1N1)pdm09 infection. Rapid diagnosis and early antiviral therapy are necessary for managing influenza pneumonia during epidemic periods.

      Keywords

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