The nucleotide analogue, tenofovir disoproxil fumarate (DF), a drug effective against
HIV and hepatitis B, is considered to have a favourable toxicity profile.
1.
In short-term clinical trials, tenofovir DF did not exhibit more frequent nephrotoxicity
compared to placebo. Recently, however, case reports of acute renal failure and Fanconi
syndrome have been described.
2.
,
3.
,
4.
,
5.
We report a patient who developed a Fanconi syndrome and rhabdomyolysis two months
after the initiation of tenofovir DF.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of InfectionAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors.Antiviral Res. 2002; 54: 37-45
- Rapid communication: acute renal failure associated with fenofovir; evidence of drug-induced nephrotoxicity.Am J Med Sci. 2002; 324: 342-344
- Fanconi syndrome and renal failure induced by tenofovir: a first case report.Am J Kidney Dis. 2002; 40: 1331-1333
Reynes J, Peyriere H, Marle de Boever C, et al. Renal tubular injury and severe hypophosphoremia (Fanconi syndrome) associated with tenofovir therapy. Tenth Conference on Retroviruses and Opportunistic Infections, Boston, MA; 10–14 February 2003. Abstract 717.
Blick G, Greiger-Zanlungo P, Garton T, et al. Tenofovir may cause severe hypophosphatemia in HIV/AIDS patients with prior adefovir-induced renal tubular acidosis. Tenth Conference on Retroviruses and Opportunistic Infections, Boston, MA; 10–14 February 2003. Abstract 718.
- Marked elevation of the creatine phosphokinase level in a patient receiving tenofovir.Clin Infect Dis. 2002; 35: 1137
- Hypokalemia causing rhabdomyolysis and precordialgia.Intensive Care Med. 2001; 27: 1096
- Introduction to bone and mineral metabolism.in: Braunwald E. Fauci A.S. Kasper D.L. Hauser S.L. Longo D.L. Jameson J.L. Harrison's 15th Edition Principles of Internal Medicine. McGraw-Hill, New York2001: 2192-2207
Article info
Identification
Copyright
© 2003 The British Infection Society. Published by Elsevier Inc. All rights reserved.
