Journal of Infection
Volume 60, Issue 5 , Pages 397-399 , May 2010

Surveillance non-directed bronchial lavage allows confident use of focused antibiotics in the management of ventilator-associated pneumonia

  • Tim Felton

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +44 1614451304.

,Accepted 24 February 2010.

References 

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  2. Iregui M, Ward S, Sherman G, Fraser VJ, Kollef MH. Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest. 2002;122(1):262–268
  3. Joffe A, Muscedere J, Marshall J, Su Y, Heyland D. The safety of targeted antibiotic therapy for ventilator-associated pneumonia: a multicenter observational study. J Crit Care. 2008;23:82–90
  4. Thomas J, Forrest A, Bhavani S. Pharmacodynamic evaluation of factors associated with the development of bacterial resistance in acutely ill patients during therapy. Antimicrob Agents Chemother. 1998;42:521–527
  5. Cardenosa Cendrero JA, Sole-Violan J, Bordes Benitez A, Noguera Catalan J, Arroyo Fernandez J, Saavedra Santana P, et al. Role of different routes of tracheal colonization in the development of pneumonia in patients receiving mechanical ventilation. Chest. 1999;116(2):462–470
  6. Cook D, Mandell L. Endotracheal aspiration in the diagnosis of ventilator-associated pneumonia. Chest. 2000;117(4 Suppl. 2):195S–197S
  7. Campbell GD. Blinded invasive diagnostic procedures in ventilator-associated pneumonia. Chest. 2000;117(4 Suppl. 2):207S–211S
  8. Pugin J, Auckenthaler R, Mili N, Janssens JP, Lew PD, Suter PM. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic “blind” bronchoalveolar lavage fluid. Am Rev Respir Dis. 1991;143(5 Pt 1):1121–1129
  9. A'Court CH, Garrard CS, Crook D, Bowler I, Conlon C, Peto T, et al. Microbiological lung surveillance in mechanically ventilated patients, using non-directed bronchial lavage and quantitative culture. Q J Med. 1993;86(10):635–648
  10. Chastre J, Fagon JY. Ventilator-associated pneumonia. Am J Respir Crit Care Med. 2002;165(7):867–903
  11. Masterton RG, Galloway A, French G, Street M, Armstrong J, Brown E, et al. Guidelines for the management of hospital-acquired pneumonia in the UK: report of the working party on hospital-acquired pneumonia of the British Society for Antimicrobial Chemotherapy. J Antimicrob Chemother. 2008;62:5–34
  12. Boots RJ, Phillips GE, George N, Faoagali J. Surveillance culture utility and safety using low-volume blind bronchoalveolar lavage in the diagnosis of ventilator-associated pneumonia. Respirology. 2008;13(1):87–96

PII: S0163-4453(10)00055-1

doi: 10.1016/j.jinf.2010.02.012

Journal of Infection
Volume 60, Issue 5 , Pages 397-399 , May 2010

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