Journal of Infection
Volume 60, Issue 4 , Pages 293-299 , April 2010

Rapid MRSA test in exposed persons: Costs and savings in hospitals

  • B.M. Andersen

      Affiliations

    • Department of Hospital Infections, Oslo University Hospital – Ullevål, Oslo, Norway
    • Diakonova University College, Oslo, Norway
    • Corresponding Author InformationCorresponding author. Department of Hospital Infections, Oslo University Hospital – Ullevål, Oslo, Norway. Tel.: +47 22 11 99 87, +47 975 80 570.
  • ,
  • T. Tollefsen

      Affiliations

    • Department of Hospital Infections, Oslo University Hospital – Ullevål, Oslo, Norway
  • ,
  • B. Seljordslia

      Affiliations

    • Department of Hospital Infections, Oslo University Hospital – Ullevål, Oslo, Norway
  • ,
  • K. Hochlin

      Affiliations

    • Department of Hospital Infections, Oslo University Hospital – Ullevål, Oslo, Norway
  • ,
  • G. Syversen

      Affiliations

    • Department of Microbiology, Oslo University Hospital – Ullevål, Oslo, Norway
  • ,
  • T.Ø. Jonassen

      Affiliations

    • Department of Microbiology, Oslo University Hospital – Ullevål, Oslo, Norway
  • ,
  • M. Rasch

      Affiliations

    • Department of Hospital Infections, Oslo University Hospital – Ullevål, Oslo, Norway
  • ,
  • L. Sandvik

      Affiliations

    • Centre for Clinical Research, Oslo University Hospital – Ullevål, Oslo, Norway

,Accepted 23 January 2010.

References 

  1. Bøcher S, Gervelmeyer A, Monnet DL, Mølbak K, Skov RL The Danish CA-MRSA Study Group. Methicillin-resistant Staphylococcus aureus: risk factors associated with community-onset infections in Denmark. Clin Microbiol Infect. 2008;14:942–948
  2. Epi-Nyt . MRSA-udbrud på neonatalafdelinger. EPI-NYT. 2008;48:
  3. Andersen BM, Rasch M, Syversen G. Is an increase of MRSA in Oslo, Norway, associated with changed infection control policy?. J Infect. 2007;55:531–538
  4. Ben-David D, Mermel LA, Parenteau S. Methicillin-resistant Staphylococcus aureus transmission: the possible importance of unrecognized health care worker carriage. Am J Infect Control. 2008;36:93–97
  5. Norwegian Institute of Public Health. Methicillin-resistant Staphylococcus aureus (MRSA) guideline; 2008.
  6. Harbarth S, Frankhauser C, Schrenzel J, Christenson J, Gervaz P, Bandiera-Clerc C, et al. Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients. JAMA. 2008;299:1149–1157
  7. Aldeyab MA, Kearney MP, Hughes CM, Scott MG, Tunney MM, Gilpin DG, et al. Can the use of a rapid polymerase chain screening method decrease the incidence of nosocomial methicillin-resistant Staphylococcus aureus?. J Hosp Infect. 2009;71:22–28
  8. Jog S, Cunningham R, Cooper S, Wallis M, Marchbank A, Vasco-Knight P, et al. Impact of preoperative screening for methicillin-resistant Staphylococcus aureus by real-time polymerase chain reaction in patients undergoing cardiac surgery. J Hosp Infect. 2008;69:124–130
  9. Wolk DM, Struelens MJ, Pancholi P, Davis T, Della-Latta P, Fuller D, et al. Rapid detection of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) in wound specimens and blood cultures: multicenter preclinical evaluation of the Cepheid Xpert MRSA/SA skin and soft tissue and blood culture assays. J Clin Microbiol. 2009;47:823–826
  10. Wolk DM, Picton E, Johnson D, Davis T, Pancholi P, Ginocchio CC, et al. Multicenter evaluation of the Cepheid Xpert methicillin-resistant Staphylococcus aureus (MRSA) test as a rapid screening method for detection of MRSA in nares. J Clin Microbiol. 2009;47:758–764
  11. Rossney AS, Herra CM, Brennan GI, Morgan PM, O'Connell B. Evaluation of the Xpert methicillin-resistant Staphylococcus aureus (MRSA) assay using the GeneXpert real-time PCR platform for rapid detection of MRSA from screening specimens. J Clin Microbiol. 2008;46:3285–3290
  12. Xpert MRSA, Cepheid.300-5188 Rev.C, Package insert; October 2007.
  13. Andersen BM, Lindemann R, Bergh K, Nesheim BI, Syversen G, Solheim N, et al. Spread of methicillin-resistant Staphylococcus aureus in a neonatal intensive unit associated with understaffing, overcrowding and mixing of patients. J Hosp Infect. 2002;1:1–7
  14. Andersen BM, Rasch M, Hochlin K, Tollefsen T, Sandvik L. Hospital-acquired infections before and after healthcare reorganization in a tertiary university hospital in Norway. J Publ Health. 2009;31:98–104
  15. Andersen BM, Rasch M, Hochlin K, Jensen JF, Wismar P, Fredriksen JE. Decontamination of rooms, medical equipment and ambulances, using a dry mist of hydrogen peroxide disinfectant. J Hosp Infect. 2006;62:149–155
  16. Lydersen S, Fageland MW, Laake P. Tutorial in biostatistics. Recommended tests for association in 2×2 tables. Stat Med. 2009;28:1159–1175
  17. Oie S, Suenaga S, Sawa A, Kamiya A. Association between isolation sites of methicillin-resistant Staphylococcus aureus (MRSA) in patients with MRSA-positive body sites and MRSA contamination in their surrounding environmental surfaces. Jpn J Infect Dis. 2007;60:367–369
  18. Coello R, Jiminez J, Garcia M, Arroyo P, Minguez D, Fernandez C, et al. Prospective study of infection, colonization and carriage of methicillin-resistant Staphylococcus aureus in an outbreak affecting 990 patients. Eur J Clin Microbiol Infect Dis. 1994;13:74–81
  19. Pearman JW, Grubb WB. Preventing the importation and establishment of methicillin-resistant Staphylococcus aureus (MRSA) in hospitals in Western Australia. APUA Newslett. 1993;11:1–8
  20. Cox RA, Conquest C. Strategies for the management of healthcare staff colonized with epidemic methicillin-resistant Staphylococcus aureus. J Hosp Infect. 1997;35:117–127
  21. Meurman O, Routamaa M, Peltonen R. Screening for methicillin-resistant Staphylococcus aureus: which anatomical sites to culture?. J Hosp Infect. 2005;61:351–353
  22. Eveillard M, de Lassence A, Barnaud G, Ricard J-D, Joly-Guillou M-L. Evaluation of a strategy of screening multiple anatomical sites for methicillin-resistant Staphylococcus aureus at admission to a teaching hospital. Infect Control Hosp Epidemiol. 2006;27:181–184
  23. Calfee DP, Salgado CD, Classen D, Arias KM, Podgorny K, Anderson DJ, et al. Strategies to prevent transmission of methicillin-resistant Staphylococcus aureus in acute care hospitals. Infect Control Hosp Epidemiol. 2008;29:S62–S80
  24. Dancer SJ. Considering the introduction of universal MRSA screening. J Hosp Infect. 2008;69:315–320
  25. Nulens E, Broex E, Ament A, Deurenberg RH, Smeets E, Scheres J, et al. Cost of the methicillin-resistant Staphylococcus aureus search and destroy policy in a Dutch university hospital. J Hosp Infect. 2008;68:301–307

PII: S0163-4453(10)00025-3

doi: 10.1016/j.jinf.2010.01.008

Journal of Infection
Volume 60, Issue 4 , Pages 293-299 , April 2010