Journal of Infection
Volume 60, Issue 3 , Pages 229-237 , March 2010

Clinical, epidemiological and virological features of dengue virus infections in vietnamese patients presenting to primary care facilities with acute undifferentiated fever

  • Khoa T.D. Thai

      Affiliations

    • Division of Infectious Diseases, Tropical Medicine & AIDS, Academic Medical Center, F4-217, P.O. Box 22700, Amsterdam 1100 DE, the Netherlands
    • Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Viet Nam
    • Center for Infection and Immunity (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
    • Corresponding Author InformationCorresponding author. Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam. Tel.: +84 8 9237954; fax: +84 8 9238904.
  • ,
  • Hoang Lan Phuong

      Affiliations

    • Division of Infectious Diseases, Tropical Medicine & AIDS, Academic Medical Center, F4-217, P.O. Box 22700, Amsterdam 1100 DE, the Netherlands
    • Tropical Diseases Clinical Research Center, Cho Ray hospital, Ho Chi Minh City, Viet Nam
  • ,
  • Tran Thi Thanh Nga

      Affiliations

    • Department of Virology, Cho Ray Hospital, Ho Chi Minh City, Viet Nam
  • ,
  • Phan Trong Giao

      Affiliations

    • Tropical Diseases Clinical Research Center, Cho Ray hospital, Ho Chi Minh City, Viet Nam
  • ,
  • Le Quoc Hung

      Affiliations

    • Tropical Diseases Clinical Research Center, Cho Ray hospital, Ho Chi Minh City, Viet Nam
  • ,
  • Nguyen Van Nam

      Affiliations

    • Binh Thuan Medical College, Phan Thiet City, Viet Nam
  • ,
  • Tran Quang Binh

      Affiliations

    • Tropical Diseases Clinical Research Center, Cho Ray hospital, Ho Chi Minh City, Viet Nam
  • ,
  • Cameron Simmons

      Affiliations

    • Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Viet Nam
    • Center for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Center for Clinical Vaccinology and Tropical Medicine, Oxford, UK
  • ,
  • Jeremy Farrar

      Affiliations

    • Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Viet Nam
    • Center for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Center for Clinical Vaccinology and Tropical Medicine, Oxford, UK
  • ,
  • Tran Thinh Hien

      Affiliations

    • Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Viet Nam
  • ,
  • H. Rogier van Doorn

      Affiliations

    • Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Viet Nam
    • Center for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Center for Clinical Vaccinology and Tropical Medicine, Oxford, UK
  • ,
  • Menno D. de Jong

      Affiliations

    • Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Viet Nam
    • Division of Medical Microbiology, Academic Medical Center, Amsterdam, the Netherlands
    • Center for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Center for Clinical Vaccinology and Tropical Medicine, Oxford, UK
  • ,
  • Peter J. de Vries

      Affiliations

    • Division of Infectious Diseases, Tropical Medicine & AIDS, Academic Medical Center, F4-217, P.O. Box 22700, Amsterdam 1100 DE, the Netherlands
    • Center for Infection and Immunity (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

,Accepted 10 January 2010.

References 

  1. World Health Organization . Dengue haemorrhagic fever. Diagnosis, treatment and control. 2nd ed.. Geneva: WHO; 1997;
  2. Gubler DJ. Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol. 2002 Feb;10(2):100–103
  3. Beatty M, Letson W, Edgil D, Margolis H. Estimating the total world population at risk for locally acquired dengue infection. Abstract presented at the 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene. Am J Trop Med Hyg. 2007;77(Suppl. 5):170–257
  4. Black WC, Bennett KE, Gorrochotegui-Escalante N, Barillas-Mury CV, Fernandez-Salas I, de Lourdes MM, et al. Flavivirus susceptibility in Aedes aegypti. Arch Med Res. 2002 Jul;33(4):379–388
  5. Rigau-Perez JG, Clark GG, Gubler DJ, Reiter P, Sanders EJ, Vorndam AV. Dengue and dengue haemorrhagic fever. Lancet. 1998 Sep 19;352(9132):971–977
  6. Burke DS, Nisalak A, Johnson DE, Scott RM. A prospective study of dengue infections in Bangkok. Am J Trop Med Hyg. 1988 Jan;38(1):172–180
  7. Kyle JL, Harris E. Global spread and persistence of dengue. Annu Rev Microbiol. 2008;62:71–92
  8. Ha DQ, Tien NT, Huong VT, Loan HT, Thang CM. Dengue epidemic in southern Vietnam, 1998. Emerg Infect Dis. 2000 Jul;6(4):422–425
  9. Phuong HL, de Vries PJ, Nagelkerke N, Giao PT, Hung LQ, Binh TQ, et al. Acute undifferentiated fever in Binh Thuan province, Vietnam: imprecise clinical diagnosis and irrational pharmaco-therapy. Trop Med Int Health. 2006 Jun;11(6):869–879
  10. Phuong HL, de Vries PJ, Nga TT, Giao PT, Hung LQ, Binh TQ, et al. Dengue as a cause of acute undifferentiated fever in Vietnam. BMC Infect Dis. 2006;6:123
  11. Thai KT, Binh TQ, Giao PT, Phuong HL, Hung LQ, Van Nam N, et al. Seroprevalence of dengue antibodies, annual incidence and risk factors among children in southern Vietnam. Trop Med Int Health. 2005 Apr;10(4):379–386
  12. Thai KT, Nga TT, Van Nam N, Phuong HL, Giao PT, Hung LQ, et al. Incidence of primary dengue virus infections in southern Vietnamese children and reactivity against other flaviviruses. Trop Med Int Health. 2007 Dec;12(12):1553–1557
  13. Neff JM, Morris L, Gonzalez-Alcover R, Coleman PH, Lyss SB, Negron H. Dengue fever in a Puerto Rican community. Am J Epidemiol. 1967 Jul;86(1):162–184
  14. Tran TN, de Vries PJ, Hoang LP, Phan GT, Le HQ, Tran BQ, et al. Enzyme-linked immunoassay for dengue virus IgM and IgG antibodies in serum and filter paper blood. BMC Infect Dis. 2006;6:13
  15. Phuong HL, Thai KT, Nga TT, Giao PT, Hung LQ, Binh TQ, et al. Detection of dengue nonstructural 1 (NS1) protein in Vietnamese patients with fever. Diagn Microbiol Infect Dis. 2009 Feb 16;
  16. Dussart P, Labeau B, Lagathu G, Louis P, Nunes MR, Rodrigues SG, et al. Evaluation of an enzyme immunoassay for detection of dengue virus NS1 antigen in human serum. Clin Vaccine Immunol. 2006 Nov;13(11):1185–1189
  17. Boom R, Sol C, Beld M, Weel J, Goudsmit J, Wertheim-van Dillen P. Improved silica-guanidiniumthiocyanate DNA isolation procedure based on selective binding of bovine alpha-casein to silica particles. J Clin Microbiol. 1999 Mar;37(3):615–619
  18. Laue T, Emmerich P, Schmitz H. Detection of dengue virus RNA in patients after primary or secondary dengue infection by using the TaqMan automated amplification system. J Clin Microbiol. 1999 Aug;37(8):2543–2547
  19. Phuong HL, de Vries PJ, Thai KT, Nga TT, Hung LQ, Giao PT, et al. Dengue virus infections in Vietnam: tip of the iceberg. Dengue Bull. 2006;30:15–25
  20. Ha DQ, Huong VT, Loan HT, Ngu VTT, Dao HTN, Thang CM. Virological and serological surveillence of dengue epidemics in 19 provinces in southern Vietnam during 2001. Dengue Bull. 2003;27:46–51
  21. Nisalak A, Endy TP, Nimmannitya S, Kalayanarooj S, Thisayakorn U, Scott RM, et al. Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999. Am J Trop Med Hyg. 2003 Feb;68(2):191–202
  22. Guzman MG, Kouri G. Dengue: an update. Lancet Infect Dis. 2002 Jan;2(1):33–42
  23. Kuberski T, Rosen L, Reed D, Mataika J. Clinical and laboratory observations on patients with primary and secondary dengue type 1 infections with hemorrhagic manifestations in Fiji. Am J Trop Med Hyg. 1977 Jul;26(4):775–783
  24. Murgue B, Roche C, Chungue E, Deparis X. Prospective study of the duration and magnitude of viraemia in children hospitalised during the 1996–1997 dengue-2 outbreak in French Polynesia. J Med Virol. 2000 Apr;60(4):432–438
  25. Yeh WT, Chen RF, Wang L, Liu JW, Shaio MF, Yang KD. Implications of previous subclinical dengue infection but not virus load in dengue hemorrhagic fever. FEMS Immunol Med Microbiol. 2006 Oct;48(1):84–90
  26. Thomas L, Verlaeten O, Cabie A, Kaidomar S, Moravie V, Martial J, et al. Influence of the dengue serotype, previous dengue infection, and plasma viral load on clinical presentation and outcome during a dengue-2 and dengue-4 co-epidemic. Am J Trop Med Hyg. 2008 Jun;78(6):990–998
  27. Balmaseda A, Hammond SN, Perez L, Tellez Y, Saborio SI, Mercado JC, et al. Serotype-specific differences in clinical manifestations of dengue. Am J Trop Med Hyg. 2006 Mar;74(3):449–456
  28. Thein S, Aung MM, Shwe TN, Aye M, Zaw A, Aye K, et al. Risk factors in dengue shock syndrome. Am J Trop Med Hyg. 1997 May;56(5):566–572
  29. Graham RR, Juffrie M, Tan R, Hayes CG, Laksono I, Ma'roef C, et al. A prospective seroepidemiologic study on dengue in children four to nine years of age in Yogyakarta, Indonesia I. studies in 1995–1996. Am J Trop Med Hyg. 1999 Sep;61(3):412–419
  30. Harris E, Videa E, Perez L, Sandoval E, Tellez Y, Perez ML, et al. Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua. Am J Trop Med Hyg. 2000 Jul;63(1–2):5–11
  31. Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, et al. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis. 2000 Jan;181(1):2–9
  32. Agarwal R, Kapoor S, Nagar R, Misra A, Tandon R, Mathur A, et al. A clinical study of the patients with dengue hemorrhagic fever during the epidemic of 1996 at Lucknow, India. Southeast Asian J Trop Med Public Health. 1999 Dec;30(4):735–740
  33. Goh KT, Ng SK, Chan YC, Lim SJ, Chua EC. Epidemiological aspects of an outbreak of dengue fever/dengue haemorrhagic fever in Singapore. Southeast Asian J Trop Med Public Health. 1987 Sep;18(3):295–302
  34. Vietnam Ministry of Health & General Statistics. Population and Housing Census Vietnam; 1999. Available at: <http://www.gso.gov.vn/default.aspx?tabid = 503&ItemID = 1841>
  35. Teerawichitchainan B, Phillips JF. Ethnic differentials in parental health seeking for childhood illness in Vietnam. Soc Sci Med. 2008 Mar;66(5):1118–1130
  36. Phuong HL, de Vries PJ, Boonshuyar C, Binh TQ, Nam NV, Kager PA. Dengue risk factors and community participation in Binh Thuan Province, Vietnam, a household survey. Southeast Asian J Trop Med Public Health. 2008 Jan;39(1):79–89

PII: S0163-4453(10)00007-1

doi: 10.1016/j.jinf.2010.01.003

Journal of Infection
Volume 60, Issue 3 , Pages 229-237 , March 2010