Journal of Infection
Volume 60, Issue 3 , Pages 238-243 , March 2010

Circulating antibodies to endogenous erythropoietin and risk for HIV-1-related anemia

  • Aristotelis Tsiakalos

      Affiliations

    • Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, 11527 Athens, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30 210 7462643; fax: +30 22910 41777.
  • ,
  • Theodore Kordossis

      Affiliations

    • Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, 11527 Athens, Greece
  • ,
  • Panayiotis D. Ziakas

      Affiliations

    • Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, 11527 Athens, Greece
  • ,
  • Athanasios N. Kontos

      Affiliations

    • Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, 11527 Athens, Greece
  • ,
  • Despina Kyriaki

      Affiliations

    • Department of Nuclear Medicine, Laikon General Hospital, Agiou Thoma 8, 11527 Athens, Greece
  • ,
  • Nikolaos V. Sipsas

      Affiliations

    • Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, 11527 Athens, Greece

,Accepted 18 December 2009.

References 

  1. Belperio PS, Rhew DC. Prevalence and outcomes of anemia in individuals with human immunodeficiency virus: a systematic review of the literature. Am J Med. 2004;116:27–43
  2. Sullivan PS, Hanson DL, Chu SY, Jones JL, Ward JW for the Adult/Adolescent Spectrum of Disease Group. Epidemiology of anemia in human immunodeficiency virus (HIV)-infected persons. Results from a multistate adult and adolescent spectrum of HIV disease surveillance project. Blood. 1998;91:301–308
  3. Mildvan D, Creagh T, Leitz G. Prevalence of anemia and correlation with biomarkers and specific antiretroviral regimens in 9690 human-immunodeficiency-virus-infected patients: findings of the Anemia Prevalence Study. Curr Med Res Opin. 2007;23:343–355
  4. Kreuzer KA, Rockstroh JK. Pathogenesis and pathophysiology of anemia in HIV infection. Ann Hematol. 1997;75:179–187
  5. Calore EE, Tanaka PY, Perez NM, de Almeida LV. Bone marrow pathology in AIDS. Pathol Res Pract. 2004;200:591–597
  6. Spivac JL, Barnes DC, Fuchs E, Quinn TA. Serum immunoreactive erythropoietin in HIV-1 infected patients. JAMA. 1989;261:3104–3107
  7. Kreuzer KA, Rockstroh JK, Jelkmann W, Theisen A, Spengler U, Sauerbruch T. Inadequate erythropoietin response to anemia in HIV patients: relationship to serum levels of tumor necrosis factor-alpha, interleukin 6 and their soluble receptors. Br J Haematol. 1997;96:235–239
  8. Saif MW. HIV-associated autoimmune hemolytic anemia: an update. AIDS Patient Care STDS. 2001;15:217–224
  9. Herzlich BC, Schiano TD, Moussa Z, Zimbalist E, Panagopoulos G, Ast A, et al. Decreased intrinsic factor secretion in AIDS: relation to parietal cell acid secretory capacity and vitamin B12 malabsorption. Am J Gastroenterol. 1992;87:1781–1788
  10. Montero A, Giovannoni AG, Fernandez MA, Pons-Estel B, Sen L. Autoantibodies in human immunodeficiency virus-infected patients with and without concurrent hepatitis C infection. Arthritis Rheum. 1998;41:2077–2079
  11. Kordossis T, Piha L, Guialis A, Kosmopoulou O, Tzioufas AG, Moutsopoulos HM. Non-organ specific autoantibodies against cellular components in HIV-1 infected individuals. Clin Exp Rheumatol. 1997;15:185–188
  12. Williams WM, Whalley AS, Comacchio RM, Rosenberg J, Watts RA, Isenberg DA, et al. Correlation between expression of antibodies to histone H2B and clinical activity in HIV-infected individuals. Clin Exp Immunol. 1996;104:18–24
  13. Massabki PS, Accetturi C, Nishie IA, da Silva NP, Sato EI, Andrade LEC. Clinical implications of autoantibodies in HIV infection. AIDS. 1997;11:1845–1850
  14. Sipsas NV, Kokori SI, Ioannidis JPA, Kyriaki D, Tzioufas AG, Kordossis T. Circulating autoantibodies to erythropoietin are associated with HIV-1 related anaemia. J Infect Dis. 1999;180:2044–2047
  15. Tzioufas AG, Kokori SI, Petrovas CI, Moutsopoulos HM. Autoantibodies to human recombinant erythropoietin in patients with systemic lupus erythematosus. Arthritis Rheum. 1997;40:2212–2216
  16. Zeger SL, Liang KY, Albert PS. Models for longitudinal data: a generalized estimating equation approach. Biometrics. 1998;44:1049–1060
  17. Lipsitz SR, Fitzmaurice GM, Orav EJ, Laird NM. Performance of generalized estimating equations in practical situations. Biometrics. 1994;50:270–278
  18. Majluf-Cruz A, Luna-Castanos G, Nieto-Cisneros L. AIDS-related pure red cell aplasia. Am J Hematol. 1996;51:171
  19. Ziakas PD, Papadaki H, Psyllaki M, Voulgarelis M. Anti-thrombopoietin antibodies suppress megakaryocytic colony formation in vitro in patients with systemic lupus erythematosus. Ann Rheum Dis. 2008;67:1643–1644
  20. Casadevall N, Dupuy E, Molho-Sabatier P, Tobelem G, Varet B, Mayeux P. Autoantibodies against erythropoietin in a patient with pure red cell aplasia. N Engl J Med. 1996;334:630–633
  21. Barosi G. Inadequate erythropoietin response to anemia: definition and clinical relevance. Ann Hematol. 1994;68:215–223
  22. Fischl M, Galpin JE, Levine JD, Groopman JE, Henry DH, Kennedy P, et al. Recombinant human erythropoietin for patients with AIDS treated with zidovudine. N Engl J Med. 1990;322:1488–1493
  23. Chng WJ, Tan LK, Liu TC. Cyclosporine treatment for patients with CRF who developed pure red blood cell aplasia following EPO therapy. Am J Kidney Dis. 2003;41:692–695
  24. Sawada K, Fujishima N, Hirokawa M. Acquired pure red cell aplasia: updated review of treatment. Br J Haematol. 2008;142:505–514
  25. Semba RD, Shah N, Klein RS, Mayer KH, Scuman P, Vlahov D Human Immunodeficiency Virus Epidemiology Research Study Group. Highly active antiretroviral therapy associated with improved anemia among HIV-infected women. AIDS Patient Care STDS. 2001;15:473–480
  26. Moore RD, Forney D. Anemia in HIV-infected patients receiving highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2002;29:54–57
  27. Semba RD, Shah N, Vlahov D. Improvement of anemia among HIV-infected injection drug users receiving highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2001;26:315–319

PII: S0163-4453(09)00397-1

doi: 10.1016/j.jinf.2009.12.013

Journal of Infection
Volume 60, Issue 3 , Pages 238-243 , March 2010