Journal of Infection
Volume 60, Issue 3 , Pages 218-223 , March 2010

Early identification of leptospirosis-associated pulmonary hemorrhage syndrome by use of a validated prediction model

  • Paulo C.F. Marotto

      Affiliations

    • Intensive Care Unit, Emílio Ribas Institute of Infectology, Sao Paulo, SP, Brazil
    • Corresponding Author InformationCorresponding author at: Unidade de Terapia Intensiva, Institudo de Infectologia Emílio Ribas, Av. Dr. Arnaldo 165, Divisao Cientifica, Sao Paulo, SP 01246-903; Brazil. Tel.: +55 11 3896 1207; fax: +55 11 3088 3602.
    • ,
  • Albert I. Ko

      Affiliations

    • Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, BA, Brazil
    • Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, NY, USA
    • ,
  • Cristiane Murta-Nascimento

      Affiliations

    • Evaluation and Clinical Epidemiology Unit, Hospital del Mar-IMAS, Barcelona, Spain
    • CIBER in Epidemiology and Public Health (CIBERESP), Barcelona, Spain
    • ,
  • Antonio C. Seguro

      Affiliations

    • Department of Nephrology, Laboratory of Basic Science (LIM 12), University of Sao Paulo, Sao Paulo, SP, Brazil
    • ,
  • Rogerio R. Prado

      Affiliations

    • Department of Preventive Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil
    • ,
  • Marcia C. Barbosa

      Affiliations

    • Intensive Care Unit, Emílio Ribas Institute of Infectology, Sao Paulo, SP, Brazil
    • ,
  • Sergio A. Cleto

      Affiliations

    • Intensive Care Unit, Emílio Ribas Institute of Infectology, Sao Paulo, SP, Brazil
    • ,
  • José Eluf-Neto

      Affiliations

    • Department of Preventive Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil

,Accepted 7 December 2009.

References 

  1. Faine S, Adler B, Bolin C, Perolat P. Leptospira and leptospirosis. 2nd ed.. Melbourne, Australia: MediSci; 1999;
  2. Yersin V, Bovet P, Mérien F, Clément J, Laille M, VanRanst M, et al. Pulmonary haemorrhage as a predominant cause of death in leptospirosis in Seychelles. Trans R Soc Trop Med Hyg. 2000;94:71–76
  3. Levett PN. Leptospirosis. Clin Microbiol Rev. 2001;14:296–326
  4. Trevejo RT, Rigau-Pérez JG, Ashford DA, Zaki SR, Shieh WJ, Peters CJ, et al. Epidemic leptospirosis associated with pulmonary hemorrhage – Nicaragua. J Infect Dis. 1995;1998(178):1457–1463
  5. Panaphut T, Domrongkitchaiporn S, Thinkamrop B. Prognostic factors of death in leptospirosis: a prospective cohort study in Khon Kaen, Thailand. Int J Infect Dis. 2002;6:52–59
  6. Dupont H, Dupont-Perdrizet D, Perie JL, Zehner-Hansen S, Jarrige B, Daijardin JB. Leptospirosis: prognostic factors associated with mortality. Clin Infect Dis. 1997;25:720–724
  7. Ko AI, Galvão Reis M, Ribeiro Dourado CM, Johnson WD, Riley LW. Urban epidemic of severe leptospirosis in Brazil. Salvador leptospirosis study group. Lancet. 1999;354:820–825
  8. Marotto PCF, Nascimento CM, Eluf-Neto J, Marotto MS, Andrade L, Sztajnbok J, et al. Acute lung injury in leptospirosis: clinical and laboratory features, outcome, and factors associated with mortality. Clin Infect Dis. 1999;29:1561–1563
  9. Niwattayakul K, Homvijitkul J, Niwattayakul S, Khow O, Sitprija V. Hypotension, renal failure, and pulmonary complications in leptospirosis. Ren Fail. 2002;24:297–305
  10. Bharti AR, Nally JE, Ricaldi JN, Matthias MA, Diaz MM, Lovett MA, et al. Leptospirosis: a zoonotic disease of global importance. Lancet Infect Dis. 2003;3:757–771
  11. Tattevin P, Léveiller G, Flicoteaux R, Jauréguiberry S, Le Tulzo Y, Dupont M, et al. Respiratory manifestations of leptospirosis: a retrospective study. Lung. 2005;183:283–289
  12. Paganin F, Bourdin A, Dalban C, Courtin JP, Poubeau P, Borgherini G, et al. Leptospirosis in Reunion Island (Indian Ocean): analysis of factors associated with severity in 147 confirmed cases. Intensive Care Med. 2007;33:1959–1966
  13. Segura ER, Ganoza CA, Campos K, Ricaldi JN, Torres S, Silva H, et al. Clinical spectrum of pulmonary involvement in leptospirosis in a region of endemicity, with quantification of leptospiral burden. Clin Infect Dis. 2005;40:343–351
  14. Dolhnikoff M, Mauad T, Bethlem E, Carvalho CRR. Leptospiral pneumonias. Curr Opin Pulm Med. 2007;13:230–235
  15. Andrade L, de Francesco Daher E, Seguro AC. Leptospiral nephropathy. Semin Nephrol. 2008;28(4):383–394
  16. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Guia de vigilância epidemiológica/Ministério da Saúde, Secretaria de Vigilância em Saúde. 6th ed. Ministério da Saúde, Brasília. http://bvsms.saude.gov.br/bvs/publicacoes/Guia_Vig_Epid_novo2.pdf http://dtr2001.saude.gov.br/svs/epi/situacao_doencas/planilhas_doencas.htm
  17. Doudier B, Garcia S, Quennee V, Jarno P, Brouqui P. Prognostic factors associated with severe leptospirosis. Clin Microbiol Infect. 2006;12:299–300
  18. Esen S, Sunbul M, Leblebicioglu H, Eroglu C, Turan D. Impact of clinical and laboratory findings on prognosis in leptospirosis. Swiss Med Wkly. 2004;134:347–352
  19. Craig SB, Graham GC, Burns M-A, Dohnt MF, Smithe LD, McKay DB. Ann Trop Med Parasitol. 2009;103(4):333–341

PII: S0163-4453(09)00389-2

doi: 10.1016/j.jinf.2009.12.005

Journal of Infection
Volume 60, Issue 3 , Pages 218-223 , March 2010

Article Tools

* Image Usage & Resolution