Invasive pneumococcal disease in an underimmunized, high HIV prevalence population

Tasslimi, Azadeh; Wenger, Peter; Pentakota, Sri Ram; Brimacombe, Michael; Burday, Michele; Sinha, Anushua

doi:10.1016/j.jinf.2007.11.005

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Volume 56, Issue 2 , Pages 99-102, February 2008

Invasive pneumococcal disease in an underimmunized, high HIV prevalence population

Azadeh Tasslimi
- UMDNJ – School of Public Health, 65 Bergen Street, Newark, NJ 07107, USA
Peter Wenger
- UMDNJ – School of Public Health, 65 Bergen Street, Newark, NJ 07107, USA
- UMDNJ – New Jersey Medical School, 185 South Orange Avenue, MSB F506, Newark, NJ 07101, USA
- UMDNJ – University Hospital, 150 Bergen Street, Newark, NJ 07103, USA
Sri Ram Pentakota
- UMDNJ – School of Public Health, 65 Bergen Street, Newark, NJ 07107, USA
Michael Brimacombe
- UMDNJ – School of Public Health, 65 Bergen Street, Newark, NJ 07107, USA
- UMDNJ – New Jersey Medical School, 185 South Orange Avenue, MSB F506, Newark, NJ 07101, USA
Michele Burday
- UMDNJ – New Jersey Medical School, 185 South Orange Avenue, MSB F506, Newark, NJ 07101, USA
- UMDNJ – University Hospital, 150 Bergen Street, Newark, NJ 07103, USA
Anushua Sinha
- UMDNJ – School of Public Health, 65 Bergen Street, Newark, NJ 07107, USA
- UMDNJ – New Jersey Medical School, 185 South Orange Avenue, MSB F506, Newark, NJ 07101, USA
- UMDNJ – University Hospital, 150 Bergen Street, Newark, NJ 07103, USA
- Corresponding author. UMDNJ – New Jersey Medical School, Preventive Medicine and Community Health 185 South Orange Avenue, MSB F506, Newark, NJ 07101, USA. Tel.: +1 973 972 6538; fax: +1 973 972 7625.

Accepted 20 November 2007. published online 11 January 2008.

Summary

Objective

To describe the epidemiology of invasive pneumococcal disease (IPD) in a predominantly minority population with low childhood immunization rates and high HIV prevalence, during the early childhood pneumococcal vaccine (PCV7) era.

Methods

A retrospective cases series analysis of 131 patients diagnosed with IPD at University Hospital in Newark, NJ from 2000 through 2005, and who had their pneumococcal isolates serotyped, was conducted. Changes in IPD over time were analyzed with the Cochran-Armitage test and linear regression. Multivariate logistic regression was conducted to determine risk factors for non-vaccine type IPD.

Results

Ninety-two percent of cases occurred in older children (≥5years) and adults, with 53.4% occurring in the 34–49year-old age group. 90% of cases were black and 48% were HIV-infected. Among cases five years or older, there was a significant decrease in the proportion of IPD caused by vaccine serotypes (2000: 45.5%, 2001: 50.0%, 2002: 31.8%, 2003: 30.0%, 2004: 0.0%, 2005: 0.0%; p<0.0005). Concomitantly, PCV7 immunization rates among Newark infants increased (2002: 30.5%, 2003: 58.1%, 2004: 70.9%, 2005: 75.6%). Risk factors for non-vaccine type IPD included year of diagnosis and older male.

Conclusion

At-risk populations, with high HIV prevalence and relatively low infant PCV7 immunization rates, may still be benefiting from PCV7-related herd protection effects.

Keywords: Streptococcus pneumoniae, Invasive pneumococcal disease, Pneumococcal conjugate vaccine, Serotype, HIV