Journal of Infection
Volume 52, Issue 6 , Pages e177-e180 , June 2006

Hypoglycemia-induced anoxic brain injury possibly associated with levofloxacin

  • Kenneth R. Lawrence

      Affiliations

    • Department of Pharmacy and Division of Infectious Disease and Geographic Medicine, Tufts-New England Medical Center, 750 Washington Street, P.O. Box 420, Boston, MA 02111, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 617 636 3280; fax: +1 617 636 5638.
    • ,
  • May Adra

      Affiliations

    • Department of Pharmacy, Tufts-New England Medical Center, 750 Washington Street, P.O. Box 420, Boston, MA 02111, USA
    • Tel.: +1 617 636 8378; fax: +1 617 636 4567.
    • ,
  • Christopher Keir

      Affiliations

    • Department of Medicine, Tufts-New England Medical Center, 750 Washington Street, Boston, MA 02111, USA

,Accepted 24 August 2005.

References 

  1. Owens RC, Ambrose PG. Clinical use of the fluoroquinolones. Med Clin North Am. 2000;84:1447–1469
  2. Friedrick LV, Dougherty R. Fatal hypoglycemia associated with levofloxacin. Pharmacotherapy. 2004;24:1807–1812
  3. Arce FC, Bhasin RS, Pasmantier R. Severe hyperglycemia during gatifloxacin therapy in patients without diabetes. Endocr Pract. 2004;10:40–44
  4. Menzies DJ, Dorsainvil PA, Cunha BA, Johnson DH. Severe and persistent hypoglycemia due to gatifloxacin interaction with oral hypoglycemic agents. Am J Med. 2002;113:232–234
  5. Biggs WS. Hypoglycemia and hyperglycemia associated with gatifloxacin use in elderly patients. J Am Board Fam Pract. 2003;16:455–457
  6. Roberge RJ, Kaplan R, Frank R, Fore C. Glyburide–ciprofloxacin interaction with resistant hypoglycemia. Ann Emerg Med. 2000;36:160–163
  7. Coblio NA, Mowrey K, McCright P, Means H, McCormick MT. Use of a data warehouse to examine the effect of fluoroquinolones on glucose metabolism. Am J Health Syst Pharm. 2004;61:2545–2548
  8. Smith KM, Lomaestro BM. What role do fluoroquinolones antimicrobial agents play in cardiac dysfunction and altered glycemic control?. J Pharm Pract. 2003;16:349–360
  9. Kagansky N, Levey S, Rimon E, Cojocaru L, Fridman A, Ozer Z, et al. Hypoglycemia as a predictor of mortality in hospitalized elderly patients. Arch Intern Med. 2003;163:1825–1829
  10. Proctor & Gamble Pharmaceuticals. Macrodantin (nitrofurantoin) macrocapsules package insert. 2003;[Cincinnati, OH]
  11. Ortho-McNeil Pharmaceutical. Levaquin (levofloxacin) tablets/injection package insert. Laritan, NJ: Ortho-McNeil; 2004.
  12. Bayer Pharmaceuticals. Avelox (moxifloxacin) tablets/injection package insert. West Haven, CT: Bayer Pharmaceuticals; 2004.
  13. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30:239–245

PII: S0163-4453(05)00257-4

doi: 10.1016/j.jinf.2005.08.024

Journal of Infection
Volume 52, Issue 6 , Pages e177-e180 , June 2006

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